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Anosmia does not impair the anxiolytic-like effect of lavender essential oil inhalation in mice

机译：失眠不会损害小鼠薰衣草精油吸入的抗焦虑样作用

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AbstractAim The inhalation of Lavandula angustifolia (lavender) essential oil has anxiolytic-like effects in animal models and humans, but its mechanism of action is still not fully understood. The inhalation of essential oils can induce anxiolytic effects through the central nervous system (e.g., lung absorption and bloodstream transport) or stimulation of the olfactory system and secondary activation of brain regions. Thus, the main objective of the present study was to evaluate whether the perception of lavender essential oil aroma, when inhaled, is necessary to obtain its anxiolytic-like effects in mice tested in the marble-burying test. Main methods Anosmia was induced by irrigating the nasal cavity with zinc gluconate + zinc acetate so that the mice could not detect odors in the olfactory discrimination test. The marble-burying test was used to evaluate the anxiolytic-like effects of inhaled lavender essential oil. Key findings Anosmia did not interfere with the anxiolytic-like effect of lavender essential oil inhalation in the marble-burying test at concentrations of 2.5% (number of marbles buried: vehicle, 4.7 ± 1.0; zinc, 6.2 ± 2.2; p > 0.10) and 5% (number of marbles buried: vehicle, 3.4 ± 0.8; zinc, 4.3 ± 0.9; p > 0.10). Lavender essential oil at a concentration of 0.5% was ineffective. Significance These results suggest that olfactory system activation is unlikely to participate in the anxiolytic-like effect of lavender essential oil inhalation.
机译：摘要目的薰衣草精油的吸入在动物模型和人类中具有类似抗焦虑的作用，但其作用机理仍不完全清楚。吸入精油可通过中枢神经系统（例如，肺吸收和血流运输）或刺激嗅觉系统以及大脑区域的第二次激活而诱导抗焦虑作用。因此，本研究的主要目的是评估在吸入大理石时是否需要感知薰衣草精油的香气，以获得其抗焦虑样作用。主要方法通过用葡萄糖酸锌+乙酸锌冲洗鼻腔来诱发嗅觉失调，从而使小鼠在嗅觉辨别测试中无法检测到气味。大理石掩埋试验用于评估吸入的薰衣草精油的抗焦虑作用。主要发现在浓度为2.5％的大理石掩埋试验中，失眠症并未干扰薰衣草精油吸入的抗焦虑样作用（掩埋的大理石数量：媒介物为4.7±1.0;锌为6.2±2.2; p> 0.10）和5％（埋藏的大理石数量：媒介物，3.4±0.8;锌，4.3±0.9; p> 0.10）。浓度为0.5％的薰衣草精油无效。意义这些结果表明，嗅觉系统的激活不太可能参与薰衣草精油吸入的抗焦虑作用。

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