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首页> 外文期刊>Life sciences >STUDY OF THE ACTION OF INTRAMUSCULARLY ADMINISTERED ERYTHROMYCIN ON THE L-THREONINE TRANSPORT AND THE DIGESTIVE ENZYMATIC ACTIVITY IN RABBIT JEJUNUM
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STUDY OF THE ACTION OF INTRAMUSCULARLY ADMINISTERED ERYTHROMYCIN ON THE L-THREONINE TRANSPORT AND THE DIGESTIVE ENZYMATIC ACTIVITY IN RABBIT JEJUNUM

机译：肌内红霉素对兔空肠L-苏氨酸转运和消化酶活性的作用研究

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摘要

Erythromycin has been shown to inhibit the intestinal transport of L-threonine and D-galactose in strips of mucosal jejunum when it was directly added to the incubation medium. Nevertheless, the effect of erythromycin administered therapeutically by intramuscular injection on both the intestinal absorption of nutrients and the intestinal digestive activity, remains unknown. The results obtained show that, firstly, the intestinal absorption of L-threonine is inhibited in animals treated with erythromycin. The kinetic study shows that the effect seems to be mainly due to an alteration of the affinity apparent constant (Kt) of the Na+-dependent system of transport located in the mucosal border. However, the Na+-dependent L-threonine transport in BBMV was not altered by the treatment with erythromycin. The (Na+-K+) ATPase activity in BLMV from treated jejunum was 40% of the activity in control BLMV. Secondly, the treatment with erythromycin did not modify the digestive enzymatic activity of sucrase and aminopeptidase N. [References: 28]
机译：当将红霉素直接添加到培养液中时，它会抑制粘膜空肠条带中的L-苏氨酸和D-半乳糖的肠运输。然而，通过肌内注射治疗性给予的红霉素对营养物质的肠吸收和肠消化活性的作用仍是未知的。获得的结果表明，首先，在用红霉素治疗的动物中L-苏氨酸的肠吸收被抑制。动力学研究表明，该作用似乎主要是由于位于粘膜边界的依赖Na +的运输系统的亲和力表观常数（Kt）发生了变化。然而，用红霉素治疗并不能改变BBMV中Na +依赖性的L-苏氨酸的转运。空肠中BLMV中的（Na + -K +）ATPase活性是对照BLMV中的40％。其次，红霉素治疗并没有改变蔗糖酶和氨肽酶N的消化酶活性。[参考文献：28]

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