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首页> 外文期刊>Life sciences >CARDIOVASCULAR EFFECTS OF THE FUNGAL EXTRACT OF BASIDIOMYCETES SP YL8006
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CARDIOVASCULAR EFFECTS OF THE FUNGAL EXTRACT OF BASIDIOMYCETES SP YL8006

机译：细菌分支杆菌SP YL8006真菌提取物的心血管作用

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摘要

Many fungal products are known to possess biological activity towards the mammalian tissues. We studied vasodilating activity in the crude ethanol extract of the dried mycelia of Basidiomycetes sp. YL8006, cultured by submerged fermentation with a complex medium. The activity was assayed using the isolated perfused rat heart in the working mode. Immediately following injection of the extract into the perfusion system, a 20-25% increase in coronary flow was observed (p < 0.001 vs. solvent vehicle control). There was a concurrent decrease in diastolic pressure and coronary vascular resistance. Aortic flow, systolic pressure, and cardiac output declined slightly over time after treatment. No significant changes in heart rate, efficiency, and oxygen consumption were observed. Solvent vehicle did not cause any changes in hemodynamic performance. [References: 11]
机译：已知许多真菌产品对哺乳动物组织具有生物活性。我们研究了担子菌干菌丝体的粗乙醇提取物中的血管舒张活性。 YL8006，通过复杂培养基的深层发酵培养。使用分离的灌注大鼠心脏以工作模式测定活性。将提取物注射到灌注系统后，立即观察到冠状动脉血流量增加了20-25％（相对于溶剂溶媒对照，p <0.001）。舒张压和冠状动脉血管阻力同时降低。治疗后主动脉血流量，收缩压和心输出量随时间略有下降。没有观察到心率，效率和耗氧量的显着变化。溶剂载体没有引起血液动力学性能的任何变化。 [参考：11]

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