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首页> 外文期刊>Life sciences >SENSITIVITY OF HUMAN PERIPHERAL BLOOD MONONUCLEAR LEUKOCYTES TO VISIBLE LIGHT
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SENSITIVITY OF HUMAN PERIPHERAL BLOOD MONONUCLEAR LEUKOCYTES TO VISIBLE LIGHT

机译：人外周血单核白细胞对可见光的敏感性

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Overnight light exposure of cultured human peripheral blood mononuclear leukocytes [PBML], significantly increased basal [H-3]thymidine incorporation and upon stimulation with phytohemagglutinin [PHA]. Melatonin (10(-9) to 10(-5) M) enhanced the light-induced increase of [3H]thymidine incorporation, while serotonin (10(-9) to 10(-7) M) stimulated [H-3]thymidine incorporation in the dark. The wavelengths responsible of this effect were restricted to the blue-green zone of the spectrum. The stimulatory effect of visible light on PHA-induced DNA replication had a circannual rhythm, being maximal during winter. In winter, white light also reduced melatonin and serotonin binding to PBML membranes and switched the PBML indole metabolism towards serotonin and 5-hydroxy-indole-acetic acid [HIAA] synthesis, with a concomitant decrease of melatonin production. [References: 46]
机译：过夜暴露于培养的人外周血单核白细胞[PBML]，会显着增加基础[H-3]胸苷的掺入以及受植物血凝素[PHA]刺激。褪黑素（10（-9）至10（-5）M）增强了光诱导[3H]胸苷掺入的增加，而血清素（10（-9）至10（-7）M）刺激了[H-3]。胸苷在黑暗中掺入。造成这种影响的波长仅限于光谱的蓝绿色区域。可见光对PHA诱导的DNA复制的刺激作用具有周期性，在冬季最大。在冬季，白光还减少了褪黑激素和5-羟色胺与PBML膜的结合，并使PBML吲哚代谢转向5-羟色胺和5-羟基-吲哚-乙酸[HIAA]的合成，同时褪黑激素的产生也随之减少。 [参考：46]

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