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Reduction of stress-induced analgesia following ethanol exposure in mice.

机译：减少小鼠乙醇暴露后的应激诱导的镇痛作用。

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In the present study, we examined the effects of ethanol treatment on the subsequent expression of opioid and nonopioid forms of swim stress-induced analgesia (SSIA). In Experiment 1, mice were injected with ethanol (2.5 g/kg, i.p.) or an equal volume of saline once a day for two days. Animals received no treatment on day 3. On day 4, the animals were tested for opioid (3-min swim in water maintained at 32 degrees C) or nonopioid (3-min swim in water maintained at 20 degrees C) SSIA in the hotplate test (52 degrees C). Mice pretreated with ethanol injections showed a decrease in nonopioid SSIA, but not in opioid SSIA. In Experiment 2, mice were given an ethanol solution (10%) or tap water to drink for 15 days. On day 16, all animals were given tap water to drink. On day 17, the animals were tested for opioid or nonopioid SSIA. Neither form of SSIA was modified in mice that drank the ethanol solution. These results show that ethanol pretreatment can modify nonopioid endogenous analgesic responses in mice. Further, the route of administration influences the effects of ethanol pretreatment on SSIA.
机译：在本研究中，我们检查了乙醇处理对游泳应激诱导的镇痛（SSIA）的阿片和非阿片形式随后表达的影响。在实验1中，每天两次给小鼠注射乙醇（2.5 g / kg，腹腔内注射）或等体积的盐水。动物在第3天未接受治疗。在第4天，对动物进行了阿片类药物（在维持32摄氏度的水中游泳3分钟）或非阿片类药物（在维持20摄氏度的水中游泳3分钟）SSIA的测试。测试（52摄氏度）。用乙醇注射液预处理的小鼠显示非阿片类药物的SSIA降低，但阿片类药物的SSIA没有降低。在实验2中，给小鼠乙醇溶液（10％）或自来水喝15天。在第16天，给所有动物喝自来水。在第17天，测试动物的阿片样物质或非阿片样物质SSIA。在喝乙醇溶液的小鼠中，两种形式的SSIA均未得到修饰。这些结果表明乙醇预处理可以改变小鼠中非阿片样物质的内源性镇痛反应。此外，给药途径影响乙醇预处理对SSIA的作用。

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