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首页> 外文期刊>Life sciences >Targeting disruption of histamine H1 receptors in mice: behavioral and neurochemical characterization.
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Targeting disruption of histamine H1 receptors in mice: behavioral and neurochemical characterization.

机译：针对小鼠中组胺H1受体的破坏：行为和神经化学特征。

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With gene targeting, one can practically knock out a gene in vivo and create a mutant organism that completely lacks the gene product. The mutant mice lacking histamine H1 receptors was generated by the method of gene targeting. In brains of homozygous mutant mice, no specific binding of [3H]pyrilamine was seen. The mutant mice showed impaired locomotor activity and exploratory behavior in an open field and activity wheel. Behaviors of the mutant mice were examined with several other tasks such as passive avoidance test, resident-intruder aggression test and formalin test to clarify the role for the H1 receptors in behaviors. Behavioral changes observed in the mutant mice are almost compatible with those obtained by the classical pharmacological tools. In correlation to the behavioral changes in the mutant mice, 5-hydroxytryptamine release was significantly increased in the brains of mutant mice.
机译：通过基因靶向，人们几乎可以体内敲除一个基因，从而创造出一种完全缺乏基因产物的突变生物。通过基因靶向的方法产生了缺乏组胺H1受体的突变小鼠。在纯合突变小鼠的大脑中，未观察到[3H]吡拉明的特异性结合。突变小鼠在开阔的田野和活动轮上显示出自发活动和探索行为受损。还通过其他一些任务（例如被动回避测试，居民入侵者攻击测试和福尔马林测试）来检查突变小鼠的行为，以阐明H1受体在行为中的作用。在突变小鼠中观察到的行为变化与通过经典药理学工具获得的行为变化几乎相容。与突变小鼠的行为变化相关，在突变小鼠的大脑中5-羟色胺的释放显着增加。

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