• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >THE INFLUENCE OF POLYETHYLENE GLYCOL CONJUGATION ON BOVINE HEMOGLOBINS INTRINSIC EFFECT ON THE GASTROINTESTINAL SYSTEM OF THE RAT
【24h】

THE INFLUENCE OF POLYETHYLENE GLYCOL CONJUGATION ON BOVINE HEMOGLOBINS INTRINSIC EFFECT ON THE GASTROINTESTINAL SYSTEM OF THE RAT

机译：聚乙烯醇共轭对牛血红蛋白内在作用对大鼠胃肠道系统的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The purpose of this study was to determine the impact of polyethylene glycol (PEG) conjugation on bovine hemoglobin's effect on gastrointestinal (GI) blood flow and motility in the Sprague Dawley rat. This study was divided into two parts: part one assessed blood now, while the other evaluated bolus transit time through the GI. To examine blood now, thirty-two rats were divided into four experimental groups (PEG-hemoglobin, bovine hemoglobin, Ringer's Lactate and autologous blood sham). Blood flow within the superior mesenteric artery was monitored during graduated isovolemic hemodilution. In the second part of the study, GI motility was estimated by bolus transit time. Thirty-six rats were assigned to four groups (PEG-hemoglobin, bovine hemoglobin, Ringer's Lactate and no treatment sham) and following an overnight fast, the rats were given a bolus injection (25 mL/kg) of test article. Three hours following injection, they received an oral 0.3 mt gavage of a charcoal/arabic gum mixture and were later sacrificed and their GI tract evaluated. Results indicated that the infusion of bovine hemoglobin reduced both baseline blood flow through the mesenteric artery and gastrointestinal transit time. In contrast, PEG-hemoglobin maintained baseline blood flow through the mesenteric artery and had no effect on GI transit time or morphology. Therefore, PEG conjugation of bovine hemoglobin significantly attenuated its intrinsic effect on the GI system of the sat. [References: 50]
机译：这项研究的目的是确定聚乙二醇（PEG）共轭对牛血红蛋白对Sprague Dawley大鼠胃肠道（GI）血流和运动的影响。这项研究分为两个部分：第一部分现在评估血液，另一部分评估通过胃肠道的快速浓注时间。为了检查血液，现在将32只大鼠分为四个实验组（PEG-血红蛋白，牛血红蛋白，林格氏乳酸盐和自体血伪装）。在等容血液稀释过程中监测肠系膜上动脉内的血流。在研究的第二部分中，通过推注通过时间来估计胃肠动力。将三十六只大鼠分为四组（PEG-血红蛋白，牛血红蛋白，林格氏乳酸盐，无假手术），禁食过夜后，给大鼠大剂量注射（25mL / kg）测试物品。注射后三小时，他们接受了0.3吨木炭/阿拉伯树胶混合物的口服管饲，随后被处死并评估了其胃肠道。结果表明，输注牛血红蛋白减少了通过肠系膜动脉的基线血流量和胃肠道的通过时间。相反，PEG-血红蛋白维持通过肠系膜动脉的基线血流，并且对胃肠道通过时间或形态没有影响。因此，牛血红蛋白的PEG结合显着减弱了其对sat GI系统的内在作用。 [参考：50]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号