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首页> 外文期刊>Life sciences >TREATMENT WITH HALOPERIDOL OR CLOZAPINE CAUSES CHANGES IN DOPAMINE RECEPTORS BUT NOT ADENYLATE CYCLASE OR PROTEIN KINASE C IN THE RAT FOREBRAIN
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TREATMENT WITH HALOPERIDOL OR CLOZAPINE CAUSES CHANGES IN DOPAMINE RECEPTORS BUT NOT ADENYLATE CYCLASE OR PROTEIN KINASE C IN THE RAT FOREBRAIN

机译：用氟哌啶醇或氯氮平治疗可导致多巴胺受体的变化，但不会导致大鼠前脑的腺苷酸环化酶或蛋白激酶C的改变

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The effect of treating rats with daily injections of haloperidol (1 mg/kg/day) or clozapine (20 mg/kg/day) for four weeks on second messengers and dopamine receptors was studied. The binding of [H-3]forskolin to adenylate cyclase (AC), [H-3]phorbol 12,13-dibutyrate (PDBu) to protein kinase C (PKC), [H-3]SCH23390 binding to the dopamine D-1 (DA-D-1) receptor and [H-3]spiperone binding to the dopamine D-2 (DA-D-2) receptor were measured using quantitative autoradiography. The density of AC was greatest in the caudate-putamen, nucleus accumbens and olfactory tubercle, a distribution resembling that of DA-D-1 receptor. The distribution of PKC was relatively homogeneous in the forebrain. Neither haloperidol nor clozapine administration significantly altered the levels of AC or PKC in the caudate-putamen. By contrast treatment with haloperidol, but not clozapine, significantly increased the density of DA-D-2 receptors in the caudate-putamen without affecting the density of DA-D-2 receptors. By contrast, both haloperidol and clozapine increased the density of DA-D-2 receptors in the olfactory tubercle. [References: 27]
机译：研究了每天两次注射氟哌啶醇（1 mg / kg /天）或氯氮平（20 mg / kg /天）对大鼠的第二信使和多巴胺受体的治疗作用。 [H-3] forskolin与腺苷酸环化酶（AC），[H-3] phorbol 12,13-dibutyrate（PDBu）与蛋白激酶C（PKC）的结合，[H-3] SCH23390与多巴胺D-的结合使用定量放射自显影术测量1（DA-D-1）受体和与多巴胺D-2（DA-D-2）受体结合的[H-3]哌咯酮。 AC的密度在尾状-丘脑，伏隔核和嗅结节中最大，其分布类似于DA-D-1受体。 PKC在前脑中的分布相对均匀。氟哌啶醇和氯氮平均未显着改变尾状-丘脑中AC或PKC的水平。与之相反，用氟哌啶醇而不是氯氮平进行治疗，可显着增加尾状丘脑中DA-D-2受体的密度，而不会影响DA-D-2受体的密度。相反，氟哌啶醇和氯氮平均增加了嗅结节中DA-D-2受体的密度。 [参考：27]

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