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首页> 外文期刊>Life sciences >CENTRAL ADMINISTRATION OF 8-OH-DPAT AND MCPP STIMULATES PROLACTIN SECRETION IN OVARIECTOMIZED, ESTROGEN-TREATED RATS - LACK OF AN EFFECT ON TUBEROINFUNDIBULAR DOPAMINERGIC NEURON ACTIVITY
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CENTRAL ADMINISTRATION OF 8-OH-DPAT AND MCPP STIMULATES PROLACTIN SECRETION IN OVARIECTOMIZED, ESTROGEN-TREATED RATS - LACK OF AN EFFECT ON TUBEROINFUNDIBULAR DOPAMINERGIC NEURON ACTIVITY

机译：中央管理8-OH-DPAT和MCPP刺激卵巢切除，雌激素治疗的大鼠的泌乳素分泌-缺乏对肾小管上皮多巴胺能神经元活动的影响

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The effects of central administration of two serotonin receptor agonists, 8-OH-DPAT and mCPP, on tuberoinfundibular dopaminergic (TIDA) neuron activity and serum prolactin (PRL) levels in ovariectomized, estrogen-treated rats were determined. 8-OH-DPAT dose-dependently (0.1-10 mu g/rat, icv) stimulated serum PRL levels, and depressed serotonergic neuron activity in 30 min. However, the TIDA neuron activity was not affected at all. Similar treatment of mCPP was less effective than 8-OH-DPAT: only the highest dose of mCPP (10 mu g) stimulated PRL secretion and inhibited serotonergic neuron activity. No change in TIDA neuron activity was observed either. We conclude that central serotonin acts on 5-HT1 receptors to stimulate the PRL secretion, which may not involve the TIDA neurons. [References: 26]
机译：确定了集中施用两种5-羟色胺受体激动剂8-OH-DPAT和mCPP对去卵巢，经雌激素处理的大鼠的肺下腺多巴胺能（TIDA）神经元活性和血清催乳激素（PRL）水平的影响。 8-OH-DPAT在30分钟内剂量依赖性地（0.1-10μg/大鼠，icv）刺激血清PRL水平并降低血清素能神经元活性。但是，TIDA神经元的活性完全不受影响。 mCPP的类似治疗效果不及8-OH-DPAT：仅最大剂量的mCPP（10微克）刺激PRL分泌并抑制血清素能神经元活性。也没有观察到TIDA神经元活性的变化。我们得出结论，中央5-羟色胺作用于5-HT1受体以刺激PRL分泌，而PRL分泌可能不涉及TIDA神经元。 [参考：26]

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