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LOCALIZATION OF MONOAMINE OXIDASES IN HUMAN PERIPHERAL TISSUES

机译：人周围组织中单胺氧化酶的定位

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Localization of monoamine oxidases (MAO) A and B and beta-adrenoceptors, was studied in aged human peripheral tissues (age 68-80 years) by quantitative autoradiograph. The tissues analyzed were heart, lung, liver, kidney, spleen and duodenum. [H-3]Ro41-1049 and [H-3]lazabemide, two recently characterized selective radioligands, were used to map MAO-A and MAO-B respectively. The regional pattern of distribution of MAO-A and MAO-B did not differ markedly, except in kidney and especially in duodenum. Highest levels of MAOs were measured in liver, and lowest in spleen. MAO-A was more abundant than MAO-B in lung and duodenal mucosa, and the reverse was true in myocardium. These results show marked differences in the abundance and patterns of distribution of MAOs, particularly MAO-B, in human and rodent peripheral tissues. [References: 34]
机译：单胺氧化酶（MAO）A和B和β-肾上腺素受体的定位，通过定量放射自显影在老年人外周组织（年龄68-80岁）中进行了研究。分析的组织是心脏，肺，肝，肾，脾和十二指肠。 [H-3] Ro41-1049和[H-3] lazabemide（两种最近表征的选择性放射性配体）分别用于绘制MAO-A和MAO-B的图。除了肾脏，尤其是十二指肠，MAO-A和MAO-B的区域分布模式没有显着差异。肝脏中MAO的含量最高，而脾脏中的MAO含量最低。在肺和十二指肠粘膜中，MAO-A比MAO-B丰富，在心肌中则相反。这些结果表明，在人和啮齿动物外周组织中，MAO，尤其是MAO-B的丰度和分布方式存在明显差异。 [参考：34]

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