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首页> 外文期刊>Life sciences >Effect of exercise training on adipocyte-size-dependent expression of leptin and adiponectin.
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Effect of exercise training on adipocyte-size-dependent expression of leptin and adiponectin.

机译：运动训练对瘦素和脂联素的脂肪细胞大小依赖性表达的影响。

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AIMS: Our aim was to evaluate the effect of exercise training (TR) on adipocyte-size-dependent expression of leptin and adiponectin. MAIN METHODS: Male Wistar rats were divided into 2 groups, sedentary control (CR) and TR group, and both monitored for 9weeks. Adipocytes isolated from epididymal, retroperitoneal, and inguinal fat depots were independently separated into 3 fractions of different cell size, and the relationships between adipocyte size and either leptin or adiponectin mRNA were determined by real-time RT-PCR analysis. KEY FINDINGS: In epididymal and inguinal adipose tissue, positive relationships between adipocyte size and both leptin and adiponectin mRNA expression were found. Comparison of TR and CR rats showed no significant effect of TR on the slopes of the linear regression lines of correlation between leptin mRNA and adipocyte size in either adipose tissue, whereas the slopes of the regression line of correlation between adipocyte size and adiponectin mRNA were greater in TR group. Leptin levels per milliliter of plasma were significantly lower in TR than CR rats, whereas leptin levels adjusted to the 3 fat depots did not differ. TR did not affect adiponectin levels in plasma, whereas adiponectin levels adjusted to the 3 fat depots were significantly greater in TR than CR group. SIGNIFICANCE: TR-induced reduction in leptin mRNA expression was closely associated with smaller adipocyte size. However, TR amplified the adipocyte-size-dependent expression of adiponectin mRNA, suggesting that TR-induced alterations in adiponectin mRNA may also be mediated by factor(s) other than adipocyte size.
机译：目的：我们的目的是评估运动训练（TR）对瘦素和脂联素的脂肪细胞大小依赖性表达的影响。主要方法：雄性Wistar大鼠分为两组，久坐对照组（CR）和TR组，均监测9周。从附睾，腹膜后和腹股沟脂肪储库中分离出的脂肪细胞独立地分为3个不同细胞大小的部分，并通过实时RT-PCR分析确定脂肪细胞大小与瘦素或脂联素mRNA之间的关系。主要发现：在附睾和腹股沟脂肪组织中，脂肪细胞大小与瘦素和脂联素mRNA表达之间呈正相关。 TR和CR大鼠的比较显示，TR对任一脂肪组织中瘦素mRNA和脂肪细胞大小之间的线性回归线性关系的斜率没有显着影响，而脂肪细胞大小与脂联素mRNA之间的线性回归关系的斜率更大。在TR组。 TR中每毫升血浆的瘦素水平显着低于CR大鼠，而调整至3个脂肪库的瘦素水平没有差异。 TR不会影响血浆中的脂联素水平，而TR中调整到3个脂肪库的脂联素水平显着高于CR组。意义：TR诱导的瘦素mRNA表达减少与脂肪细胞较小有关。但是，TR扩增了脂联素mRNA的脂肪细胞大小依赖性表达，这表明TR诱导的脂联素mRNA改变也可能是由脂肪细胞大小以外的其他因素介导的。

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