• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Associations between use of crack cocaine and HIV-1 disease progression: research findings and implications for mother-to-infant transmission.
【24h】

Associations between use of crack cocaine and HIV-1 disease progression: research findings and implications for mother-to-infant transmission.

机译：服用可卡因与HIV-1疾病进展之间的关联：研究发现及其对母婴传播的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recent in vitro and in vivo research has suggested that cocaine has a direct effect on the pathogenesis of AIDS. These findings are confirmed by epidemiological studies linking the use of injected, inhaled, and smoked (crack) cocaine and indicators of HIV disease progression, even among adherent users of highly active antiretroviral therapy. Recent studies of vertical HIV transmission suggest that cocaine use may play a role in mother-to-child infection via alteration of maternal immune responses, enhanced viral replication in maternal immune cells, or alterations in the immune systems of neonates or infants. The purpose of this article is to review research conducted over the past several decades on associations between use of cocaine and HIV disease progression, especially among HIV+ women, and to explore its potential relevance for understanding mother-to-infant transmission of HIV.
机译：最近的体外和体内研究表明，可卡因对艾滋病的发病机理有直接影响。这些发现已被流行病学研究证实，这些研究将注射，吸入和抽烟（开裂）可卡因的使用与HIV疾病进展的指标联系起来，即使是积极抗逆转录病毒治疗的依从性使用者也是如此。最近有关垂直HIV传播的研究表明，可卡因的使用可能通过改变母亲的免疫反应，增强母亲的免疫细胞中的病毒复制或改变新生儿或婴儿的免疫系统而在母婴感染中起作用。本文的目的是回顾过去几十年间关于可卡因使用与HIV疾病进展之间的关联性的研究，尤其是在HIV +妇女中，并探讨其对理解母婴HIV传播的潜在意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号