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首页> 外文期刊>Life sciences >Age-dependent effect of ouabain on renal Na+,K+-ATPase.
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Age-dependent effect of ouabain on renal Na+,K+-ATPase.

机译：哇巴因对肾脏Na +，K + -ATPase的年龄依赖性作用。

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AIMS: This study examines the effect of chronic ouabain-treatment on renal Na(+) handling in 12-week and 52-week old rats. MAIN METHODS: Wistar Kyoto rats aged 5 weeks or 45 weeks were treated with ouabain or vehicle during 7 weeks. Blood pressure was measured in conscious animals throughout the study. After 7 weeks of treatment urinary electrolyte concentration, Na(+),K(+)-ATPase activity and alpha(1)-subunit expression were determined in 12-week and 52-week old rats. KEY FINDINGS: In 12-week and 52-week old rats ouabain produced a significant increase in systolic blood pressure. Although no differences were observed in Na(+) excretion in these animals, 12-week old ouabain-treated rats had lower Na(+),K(+)-ATPase activity in proximal tubules. However, 12-week old ouabain-treated rats had decreased fractional excretion of Na(+). In proximal tubules of 52-week old rats Na(+),K(+)-ATPase activity did not differ between vehicle and ouabain-treated groups. SIGNIFICANCE: Our results show that in Wistar Kyoto rats renal response to ouabain treatment may be age-dependent and that the hypertensive effect of ouabain is independent of the effect on renal Na(+),K(+)-ATPase.
机译：目的：这项研究检查了慢性哇巴因治疗对12周龄和52周龄大鼠肾脏Na（+）处理的影响。主要方法：5周或45周龄的Wistar Kyoto大鼠在7周内用哇巴因或赋形剂治疗。在整个研究过程中，对清醒动物的血压进行了测量。治疗7周后，尿电解质浓度，Na（+），K（+）-ATPase活性和alpha（1）-亚基表达在12周龄和52周龄大鼠中确定。主要发现：在12周龄和52周龄的大鼠中，哇巴因使收缩压显着增加。尽管在这些动物的Na（+）排泄物中未观察到差异，但是12周大的哇巴因处理的大鼠在近端小管中的Na（+），K（+）-ATPase活性较低。但是，用哇巴因治疗的12周龄大鼠的Na（+）排泄分数降低。在52周龄大鼠的近端小管中，媒介物和哇巴因治疗组之间的Na（+），K（+）-ATPase活性没有差异。意义：我们的结果表明，在Wistar Kyoto大鼠中，对哇巴因治疗的肾脏反应可能是年龄依赖性的，哇巴因的高血压作用与对肾Na（+），K（+）-ATPase的作用无关。

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