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首页> 外文期刊>Life sciences >INFLUENCE OF ACUTE AND CHRONIC MORPHINE OR STADOL ON THE SECRETION OF ADRENOCORTICOTROPHIN AND ITS HYPOTHALAMIC RELEASING HORMONE IN THE RAT
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INFLUENCE OF ACUTE AND CHRONIC MORPHINE OR STADOL ON THE SECRETION OF ADRENOCORTICOTROPHIN AND ITS HYPOTHALAMIC RELEASING HORMONE IN THE RAT

机译：急性和慢性吗啡或司他多对大鼠肾上腺皮质激素的分泌及其下丘脑释放激素的影响

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The effects of acute and chronic treatment with morphine and stadol on the functional activity of the hypothalamo-pituitary-adrenocortical (IBA) system in the rat were studied by investigating their effects on the secretion of adrenocorticotrophin (ACTH) by the pituitary gland and corticotrophin-releasing hormone(CRH) by the hypothalamus. The acute injection of morphine or stadol (3.5 mg/100 g body weight i.p.) caused a rise at 5 and 25 min followed by a fall at 90 and 120 min in the concentrations of ACTH in the plasma and adenohypophysis and in hypothalamic CRH content. It appears that, in the rat, the response of HPA system to acute morphine or stadol administration could change depending upon the time of courses. In addition, chronic morphine or stadol (0.5 mg/100 g body weight i.p, daily) administration for a period of 7 days have little effect on plasma and adenohypophysis ACTH concentrations and hypothalamic CRH content. This may indicate that drug tolerance might have developed. Conversely, repeated daily doses of morphine or stadol (2 mg/100 g body weight i.p.) for 7 days cause a significant lowering of plasma and pituitary ACTH concentrations and hypothalamic CRH content. These data suggest that the effect of both drugs is dose related. Overall, the present results are consistent with an increased release of pro-opiomelanocortin-derived peptides after acute morphine or stadol treatment for a short-term, and with a decreased release of these peptides in chronic treatment. However, the results indicate that morphine and stadol change HPA activity by acting on specific receptors in the hypothalamus and raise the possibility that opioid peptides and their receptors are physiologically important in the control of the secretion of CRH. [References: 44]
机译：通过研究其对垂体和促肾上腺皮质激素对大鼠下丘脑-垂体-肾上腺皮质（IBA）系统功能活性的影响，研究了吗啡和斯塔多的急慢性治疗作用。下丘脑释放激素（CRH）。急性注射吗啡或stadol（3.5 mg / 100 g体重，腹腔注射）在5和25分钟时引起血浆，腺垂体和下丘脑CRH含量的ACTH浓度上升，然后在90和120分钟时下降。看来，在大鼠中，HPA系统对急性吗啡或stadol给药的反应可能随疗程时间而变化。此外，持续7天的慢性吗啡或stadol（0.5 mg / 100 g体重，每天腹膜内注射）给药对血浆和腺垂体ACTH浓度和下丘脑CRH含量影响很小。这可能表明可能已经产生了耐药性。相反地​​，连续7天每天重复服用吗啡或stadol（2 mg / 100 g体重，每天），会导致血浆和垂体ACTH浓度以及下丘脑CRH含量显着降低。这些数据表明两种药物的作用均与剂量有关。总体而言，目前的结果与急性吗啡或stadol治疗后短期内opomelanocortin衍生肽的释放增加以及在慢性治疗中这些肽的释放减少一致。然而，该结果表明吗啡和stadol通过作用于下丘脑中的特定受体来改变HPA活性，并增加了阿片样肽及其受体在控制CRH分泌中具有重要生理作用的可能性。 [参考：44]

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