Interleukin-10 inhibits the down-regulation of ATP binding cassette transporter A1 by tumour necrosis factor-alpha in THP-1 macrophage-derived foam cells.

Mei CL; Chen ZJ; Liao YH; Wang YF; Peng HY; Chen Y

首页> 外文期刊>Cell biology international. >Interleukin-10 inhibits the down-regulation of ATP binding cassette transporter A1 by tumour necrosis factor-alpha in THP-1 macrophage-derived foam cells.

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Interleukin-10 inhibits the down-regulation of ATP binding cassette transporter A1 by tumour necrosis factor-alpha in THP-1 macrophage-derived foam cells.

机译：白细胞介素10抑制THP-1巨噬细胞源性泡沫细胞中肿瘤坏死因子-α对ATP结合盒转运蛋白A1的下调。

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It is suggested that cholesterol efflux mediated by ATP binding cassette transporter A1 (ABCA1) plays an important role in anti-atherogenesis. However, the effects of inflammatory cytokines on ABCA1 expression and cholesterol accumulation in foam cells are little known. This study investigates the effects of tumour necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) on ABCA1 expression and cholesterol content in THP-1 macrophage-derived foam cells. ABCA1mRNA and protein levels were determined by RT-PCR and Western blot, respectively. The total cholesterol content in THP-1 macrophage-derived foam cells was detected by the zymochemistry method. Results revealed that TNF-alpha could increase cholesterol content by down-regulating ABCA1 expression in a time-dependent manner in THP-1 macrophage-derived foam cells, which may contribute to its pro-atherosclerotic effect. In addition IL-10 time-dependently decreased cholesterol accumulation by up-regulating ABCA1 expression and inhibited the down-regulation of ABCA1 by TNF-alpha in THP-1 macrophage-derived foam cells, which may be one of the mechanisms of IL-10 contributing to its anti-atherosclerotic action.

机译：提示由ATP结合盒转运蛋白A1（ABCA1）介导的胆固醇外流在抗动脉粥样硬化中起重要作用。但是，炎症细胞因子对泡沫细胞中ABCA1表达和胆固醇积累的影响鲜为人知。这项研究调查肿瘤坏死因子-α（TNF-alpha）和白介素10（IL-10）对THP-1巨噬细胞衍生的泡沫细胞中ABCA1表达和胆固醇含量的影响。分别通过RT-PCR和Western blot测定ABCA1mRNA和蛋白质水平。通过酶化学法检测THP-1巨噬细胞源性泡沫细胞中的总胆固醇含量。结果显示，TNF-α可以通过以时间依赖性方式下调THP-1巨噬细胞衍生的泡沫细胞中ABCA1的表达来增加胆固醇含量，这可能有助于其促动脉粥样硬化作用。此外，IL-10在THP-1巨噬细胞衍生的泡沫细胞中通过上调ABCA1表达来时间依赖性地减少胆固醇积累，并抑制TNF-α对ABCA1的下调，这可能是IL-10的机制之一。有助于其抗动脉粥样硬化作用。

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《Cell biology international.》 |2007年第12期|共6页
作者
Mei CL; Chen ZJ; Liao YH; Wang YF; Peng HY; Chen Y;
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正文语种 eng
中图分类细胞生物学;
关键词
Foam Cells; GLI2 Gene; Interleukin-10; Macrophages; 泡沫细胞; 白细胞介素10; 巨噬细胞;

机译：Foam Cells;GLI2 Gene;Interleukin-10;Macrophages;泡沫细胞;白细胞介素10;巨噬细胞;

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1. Interleukin-10 inhibits the down-regulation of ATP binding cassette transporter A1 by tumour necrosis factor-alpha in THP-1 macrophage-derived foam cells. [J] . Mei CL, Chen ZJ, Liao YH, Cell biology international. . 2007,第12期

机译：白细胞介素10抑制THP-1巨噬细胞源性泡沫细胞中肿瘤坏死因子-α对ATP结合盒转运蛋白A1的下调。
2. Tertiary-butylhydroquinone upregulates expression of ATP-binding cassette transporter A1 via nuclear factor E2-related factor 2/heme oxygenase-1 signaling in THP-1 macrophage-derived foam cells [J] . LuQ., TangS.-L., LiuX.-Y., Circulation journal . 2013,第9期

机译：叔丁基氢醌通过THP-1巨噬细胞源性泡沫细胞中的核因子E2相关因子2 /血红素加氧酶-1信号上调ATP结合盒转运蛋白A1的表达。
3. Tertiary-Butylhydroquinone Upregulates Expression of ATP-Binding Cassette Transporter A1 via Nuclear Factor E2-Related Factor 2/Heme Oxygenase-1 Signaling in THP-1 Macrophage-Derived Foam Cells [J] . Qian Lu, Shi-Lin Tang, Xiao-Yan Liu, Circulation journal . 2013,第9期

机译：叔丁基氢醌通过THP-1巨噬细胞衍生的泡沫细胞中的核因子E2相关因子2 /血红素加氧酶-1信号上调ATP结合盒式转运蛋白A1的表达。
4. Change of ATP binding cassette transporter A1 and liver X receptor α expression in diabetic minipig skeletal muscle Change of LXRα/ABCA1 pathway in diabetic skeletal muscle [C] . Shi-Lin Tang, Yin Kai, Zhong-Cheng Mo, 2011 International Conference on Remote Sensing, Environment and Transportation Engineering . 2011

机译：糖尿病迷你猪骨骼肌中ATP结合盒转运蛋白A1和肝X受体α表达的变化糖尿病骨骼肌LXRα/ ABCA1途径的变化
5. Effect of liver x receptor target genes Apolipoprotein E and ATP-binding cassette transporter A1 on beta-amyloid dependent pathology in Alzheimer's disease model mice [D] . Carter, Alexis Yvonne. 2016

机译：肝X受体靶基因脂蛋白E和ATP结合盒式传输蛋白A1对阿尔茨海默病模型小鼠β-淀粉样蛋白依赖病理的影响
6. Ht31 a Protein Kinase A Anchoring Inhibitor Induces Robust Cholesterol Efflux and Reverses Macrophage Foam Cell Formation through ATP-binding Cassette Transporter A1 [O] . Loretta Ma, Fumin Dong, Maxime Denis, 2011

机译：Ht31一种蛋白激酶A锚定抑制剂可诱导强大的胆固醇外流并通过ATP结合盒式转运蛋白A1逆转巨噬细胞泡沫细胞的形成。
7. Tertiary-Butylhydroquinone Upregulates Expression of ATP-Binding Cassette Transporter A1 via Nuclear Factor E2-Related Factor 2/Heme Oxygenase-1 Signaling in THP-1 Macrophage-Derived Foam Cells [O] . Qian Lu, Shi-Lin Tang, Xiao-Yan Liu, 2013

机译：叔丁基氢醌在THP-1巨噬细胞衍生的泡沫细胞中通过核因子E2相关因子2 /血红素氧合酶-1信号传导来提高ATP结合盒式转运蛋白A1的表达

Interleukin-10 inhibits the down-regulation of ATP binding cassette transporter A1 by tumour necrosis factor-alpha in THP-1 macrophage-derived foam cells.

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