Evaluation of the age-dependent development of lymphocyte surface receptors in children.

Neubert R; Delgado I; Abraham K; Schuster C; Helge H

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Evaluation of the age-dependent development of lymphocyte surface receptors in children.

机译：评价儿童淋巴细胞表面受体的年龄依赖性发展。

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Components and functions of the immune system change during postnatal development, not only in the first years of life, but well through adolescence and even into adult life. These age-dependent changes within the immune system greatly complicate any attempt to assess pathological alterations of immunologic variables in children. The need for studies on possible substance-induced changes, including risk assessment of environmental chemicals, has increased the necessity to establish reference ranges for certain immunologic variables against which an abnormal developmental status can be evaluated. In the present study age-related changes of surface receptors on peripheral white blood cells were studied in 82 children, aged between 2 months and 17 years. The blood samples were triple labeled with monoclonal antibodies followed by a whole blood lysis technique and were subsequently analyzed by flow cytometry. Complex statistical analyses were performed in order to determine probability ranges for some immunological variables. In this paper we describe the age-dependent development of components involved in major maturational processes, including the appearance and varying expression of adhesion receptors (CD11a, CD18, CD28, CD29, CD44, CD49d and CD54) on CD4+ "helper" cells and CD8+ "suppressor and cytotoxic" cells. A clear-cut increase of high epitope density expression of the integrins on both CD4+ and CD8+ cells was noted. These results suggest that the components of immune T cells for performing adhesion by interacting with other cells and many matrix components are largely acquired during postnatal development. Maximal levels of adhesion receptor expression are reached at different ages depending on the specific T cell subpopulation.

机译：免疫系统的组成和功能不仅在生命的最初几年，而且在青春期甚至成年后都会发生变化。免疫系统中这些与年龄有关的变化极大地使评估儿童免疫学变量病理改变的任何尝试变得复杂。对可能的由物质引起的变化进行研究的需求，包括对环境化学物质的风险评估，增加了为某些免疫学变量建立参考范围的必要性，可以根据这些参考变量评估异常的发育状况。在本研究中，研究了82名年龄在2个月至17岁之间的儿童外周血白细胞表面受体的年龄相关变化。用单克隆抗体对血样进行三重标记，然后采用全血裂解技术，然后通过流式细胞仪进行分析。为了确定某些免疫学变量的概率范围，进行了复杂的统计分析。在本文中，我们描述了主要成熟过程中涉及组分的年龄依赖性发育，包括CD4 +“辅助”细胞和CD8 +上粘附受体（CD11a，CD18，CD28，CD29，CD44，CD49d和CD54）的出现和表达变化“抑制剂和细胞毒性”细胞。注意到整联蛋白在CD4 +和CD8 +细胞上的高表位密度表达的明显增加。这些结果表明，在出生后的发育过程中大量获得了通过与其他细胞相互作用而进行粘附的免疫T细胞成分和许多基质成分。根据特定的T细胞亚群，在不同年龄达到粘附受体表达的最大水平。

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《Life sciences》 |1998年第12期|共12页
作者
Neubert R; Delgado I; Abraham K; Schuster C; Helge H;
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正文语种 eng
中图分类生命的起源;生命科学总论;
关键词
Aging; Lymphocytes; Receptors; Cell Surface; Integrins; 衰老; 淋巴细胞; 受体; 细胞表面;

机译：Aging;Lymphocytes;Receptors;Cell Surface;Integrins;衰老;淋巴细胞;受体;细胞表面;

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1. Evaluation of the age-dependent development of lymphocyte surface receptors in children. [J] . Neubert R, Delgado I, Abraham K, Life sciences . 1998,第12期

机译：评价儿童淋巴细胞表面受体的年龄依赖性发展。
2. Maturation of bone marrow lymphocytes. II. Development of Fc and complement receptors and surface immunoglobulin studied by rosetting and radioautography. [J] . W C Yang, S C Miller, D G Osmond The Journal of Experomental Medicine . 1978,第5期

机译：骨髓淋巴细胞成熟。二。玫瑰花结和放射自显影研究了Fc和补体受体以及表面免疫球蛋白的发育。
3. Age-dependent expression of the HIV-1 coreceptor CCR5 on CD4+ lymphocytes in children (letter) [J] . Auewarakul P, Sangsiriwut K, Pattanapanyasat K, JAIDS: Journal of acquired immune deficiency syndromes . 2000,第3期

机译：儿童中CD4 +淋巴细胞上HIV-1受体CCR5的年龄依赖性表达（字母）
4. Toward development of bioactive, neurotransmitter-immobilized surfaces for interaction with post-synaptic membrane receptors [C] . Vu, T.Q., Saifuddin, . 2002

机译：致力于生物活性的，神经递质固定的表面与突触后膜受体相互作用的发展
5. Development of an insturmal method to evaluate insulin receptors and insulin-like growth factor-1 receptors homodimers and hybrid receptors in breast cancer. [D] . Shebani, Karima A. 2016

机译：开发了一种评估乳腺癌中胰岛素受体和胰岛素样生长因子-1受体同型二聚体和杂合受体的可靠方法。
6. Maturation of bone marrow lymphocytes. II. Development of Fc and complement receptors and surface immunoglobulin studied by rosetting and radioautography [O] . 1978

机译：骨髓淋巴细胞成熟。二。玫瑰花结和放射自显影研究Fc和补体受体以及表面免疫球蛋白的发育
7. Occupational therapy intervention with a child is based upon an understanding and appreciation of normal development. Knowledge of current concepts and theories related to child development is essential when occupational therapist evaluates children. This background information helps therapist to plan intervention for the child. The aim of this study is to make observation video about development of about one year old child. The purpose of my study is to help occupational therapy students learn about child development. My study is practice-based thesis. It includes product, which is the observation video and study rapport. I describe my whole process in my rapport. The process includes different kinds of stages. First, I studied those theories of child development, which are used in the studies of occupational therapy for children. These theories are Moseys Developmental Frame of Reference and the theory of development according to Sensory Integration Theory. These theories are the frames of reference of my study. I organize the child development areas according to child occupations and skills. Then I start to plan, film and edit my video based on the theories of child development and the principles of making a video. In my rapport I describe all the stages of my study and explain the sequence and the content of the stages. I also evaluate the process of my study. In the observation video you can see those stages of development where about one year old child is based on the frames of reference, which I have used in my study. I believe that my observation video can at least be good for inspiring occupational therapy students learning about child development. Keywords child development, learning, observation video [O] . Lehtinen Ann-Mari 2006

机译：对儿童的职业治疗干预基于对正常发育的理解和欣赏。当职业治疗师评估儿童时，与儿童发育相关的当前概念和理论的知识必不可少。这些背景信息可帮助治疗师为孩子计划干预措施。这项研究的目的是制作有关约一岁儿童发育的观察视频。我研究的目的是帮助职业治疗学生学习儿童成长。我的研究是基于实践的论文。它包括产品，这是观察视频和学习融洽的关系。我以融洽的方式描述我的整个过程。该过程包括不同阶段。首先，我研究了有关儿童发育的理论，这些理论被用于儿童的职业治疗研究中。这些理论是Moseys发展参考框架和根据感觉统合理论的发展理论。这些理论是我研究的参考框架。我根据儿童职业和技能组织儿童发展领域。然后，我根据儿童发育理论和视频制作原理开始计划，拍摄和编辑视频。在融洽的关系中，我描述了学习的所有阶段，并解释了这些阶段的顺序和内容。我还评估了我的学习过程。在观察视频中，您可以看到那些发展阶段，其中大约一岁的孩子基于我的研究框架。我相信，我的观察视频至少可以对激发职业治疗的学生学习儿童发育有帮助。关键字儿童发展，学习，观察视频
8. Murine B Lymphocyte Heterogeneity: Distribution of Complement Receptor-Bearing and Minor Lymphocyte-Stimulating B Lymphocytes Among Cells with Different Densities of Total Surface Ig and IgM1. [R] . Scher, I., Ahmed, A., Sharrow, S. O. 1977

机译：小鼠B淋巴细胞异质性：具有不同密度的总表面Ig和Igm1的细胞中具有补体受体和小淋巴细胞刺激B淋巴细胞的分布。

Evaluation of the age-dependent development of lymphocyte surface receptors in children.

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