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首页> 外文期刊>Life sciences >Protective effect of prazosin on the hydrogen peroxide-induced derangements in the isolated perfused rat heart.
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Protective effect of prazosin on the hydrogen peroxide-induced derangements in the isolated perfused rat heart.

机译：哌唑嗪对过氧化氢诱导的离体灌注大鼠心脏畸变的保护作用。

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摘要

The effect of prazosin, an alpha1-selective adrenoceptor antagonist, on the hydrogen peroxide (H2O2)-induced mechanical and metabolic derangements was studied in the isolated rat heart, which was perfused aerobically by the Langendorffs technique at a constant flow rate and driven electrically. H2O2 (600 microM) produced both mechanical dysfunction (e.g., increase in the left ventricular end-diastolic pressure) and metabolic damage (e.g., decrease in the level of adenosine triphosphate) associated with lipid peroxidation (e.g., increase in the level of malondialdehyde). The H2O2-induced mechanical and metabolic derangements were attenuated by 2.5, 5, or 10 microM prazosin, and the increase in the level of malondialdehyde was attenuated by 5 or 10 microM prazosin. Nevertheless, prazosin had practically no effects on the mechanical function and energy metabolism of the H2O2-untreated normal heart at 2.5 or 5 microM, although it reduced the mechanical function at 10 microM. Prazosin was shown to have a hydroxyl radical scavenging effect. These results suggest that prazosin attenuates the H2O2-induced mechanical and metabolic derangements probably because of attenuation of the H2O2-induced lipid peroxidation in the heart.
机译：在离体大鼠心脏中研究了prazosin（一种α1选择性肾上腺素受体拮抗剂）对过氧化氢（H2O2）引起的机械和代谢紊乱的影响，该大鼠心脏通过Langendorffs技术以恒定流速进行有氧灌注，并通过电驱动。 H2O2（600 microM）产生与脂质过氧化相关的机械功能障碍（例如，左心室舒张末期压力增加）和代谢损伤（例如，三磷酸腺苷水平降低）（例如，丙二醛水平增加） 。 H2O2引起的机械和代谢紊乱被2.5、5或10 microM哌唑嗪减弱，丙二醛水平的增加被5或10 microM哌唑嗪减弱。然而，尽管在10 microM时会降低机械功能，但哌唑嗪对未经H2O2处理的正常心脏的机械功能和能量代谢（2.5或5 microM）几乎没有影响。证明吡唑嗪具有清除羟自由基的作用。这些结果表明，哌唑嗪可减轻H2O2引起的机械和代谢紊乱，这可能是由于H2O2引起的脂质过氧化作用减弱。

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