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首页> 外文期刊>Life sciences >Effect of metyrapone administration in pregnant rats on monoamine concentration in fetal brain.
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Effect of metyrapone administration in pregnant rats on monoamine concentration in fetal brain.

机译：妊娠大鼠服用甲吡酮对胎儿脑中单胺浓度的影响。

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Studies performed in our laboratory indicate that the adrenal deprivation during gestation can greatly influence the fetal catecholamines development in several cerebral areas. The present study was undertaken to determine whether the administration of metyrapone to pregnant rats affects the content of monoamines in fetal brain at term. To test wether the content of monoamines in fetal brain is regulated, at least in part, by endogenous glucocorticoids, pregnant rats were injected for 5 days prior to delivery with metyrapone, an adrenal 11-beta-steroid hidroxylase inhibitor which crosses the placenta and blocks endogenous glucocorticoid synthesis, or saline. On day 21 of gestation, delivery of all animals was accomplished by cesarean section. The encephalons were extracted and immediately dissected in metencephalon, mesencephalon, diencephalon and telencephalon. Monoamine determination was carried out using HPLC-ED. The results obtained indicate that the metyrapone treatment increases both DA and 5-HT and their metabolites in the brain studied areas.
机译：在我们实验室进行的研究表明，妊娠期间肾上腺的剥夺可以极大地影响几个大脑区域胎儿儿茶酚胺的发育。进行本研究以确定在怀孕期间给怀孕大鼠服用甲吡酮是否会影响胎儿脑中单胺的含量。为了测试是否至少部分地通过内源性糖皮质激素调节胎脑中单胺的含量，在分娩前，给怀孕的大鼠注射了5天，然后分娩了甲吡帕酮（一种穿过胎盘和阻滞的肾上腺11-β-类固醇羟化酶抑制剂）。内源性糖皮质激素合成或生理盐水。在妊娠的第21天，通过剖宫产完成所有动物的分娩。提取脑部并立即在中脑，中脑，中脑和远脑中解剖。使用HPLC-ED进行单胺测定。获得的结果表明，甲吡哌酮治疗可增加大脑研究区域的DA和5-HT及其代谢产物。

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