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Neonatal vitamin E treatment induces long term glucocorticoid receptor changes: An unusual hormonal imprinting effect

机译:新生儿维生素E治疗会引起长期糖皮质激素受体改变:一种不寻常的激素印迹作用

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Single neonatal vitamin E treatment significantly altered the affinity (K-d) of thymic glucocorticoid receptors in male adolescent and adult rats. In six weeks old animals the affinity increased land there is a tendency for an increase in receptor density), in twelve weeks old animals the affinity decreased. The thymic glucocorticoid receptors and uterine estrogen receptors of female animals were not influenced at all. Thousandfold tocopherol did not compete with labeled dexamethasone for their receptors, suggesting that neonatal vitamin E imprinting effect was not done at direct receptorial level. (C) 1998 Elsevier Science Inc. [References: 22]
机译:单一的新生儿维生素E治疗显着改变了雄性青春期和成年大鼠胸腺糖皮质激素受体的亲和力(K-d)。在六周龄的动物中,亲和力增加,有增加受体密度的趋势。在十二周龄的动物中,亲和力下降。雌性动物的胸腺糖皮质激素受体和子宫雌激素受体完全没有受到影响。成千上万的生育酚没有与标记的地塞米松竞争它们的受体,这表明在直接受体水平上没有实现新生儿维生素E的印迹作用。 (C)1998 Elsevier Science Inc. [参考:22]

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