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首页> 外文期刊>Life sciences >Neonatal handling reduces emotional reactivity and susceptibility to learned helplessness. Involvement of catecholaminergic systems.
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Neonatal handling reduces emotional reactivity and susceptibility to learned helplessness. Involvement of catecholaminergic systems.

机译：新生儿处理会降低情绪反应和对学习到的无助感的敏感性。涉及儿茶酚胺能系统。

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摘要

Environmental circumstances during the neonatal period are critical for the establishment of adult responses to stressful environmental situations. As these responses are underpinned by adaptations in the functioning of brain neurotransmitter systems, the present study was designed to assess the mediation of noradrenergic and dopaminergic systems in the long-lasting effects of neonatal handling on both emotionality and learned helplessness behaviour. Animals received either prazosin, propranolol, haloperidol or saline before infantile handling. When the animals were 2 months old, they were subjected first to an open field test and then to the learned helplessness paradigm. Non-treated handled animals exhibited lower emotional reactivity and reduced susceptibility to helplessness compared to non-treated non-handled rats. The results suggest that noradrenergic, but not D2-dopamine receptor systems mediate the influence of neonatal handling on the acquisition of learned helplessness in the adult. Only beta-adrenoceptors appear to play a role in emotional responsiveness.
机译：新生儿时期的环境状况对于建立成年人对压力环境状况的反应至关重要。由于这些反应以大脑神经递质系统功能的适应为基础，因此本研究旨在评估去甲肾上腺素能和多巴胺能系统在新生儿处理对情绪和学习无助行为的长期影响中的介导作用。在婴儿处理之前，动物接受哌唑嗪，普萘洛尔，氟哌啶醇或生理盐水。当动物为两个月大时，首先要进行野外测试，然后再学习无助模式。与未处理的未处理大鼠相比，未处理的处理动物表现出较低的情绪反应性和对无助感的敏感性降低。结果表明，去甲肾上腺素能系统而非D2-多巴胺受体系统介导新生儿处理对成人习得性无助的获取的影响。只有β-肾上腺素能受体似乎在情绪反应中起作用。

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