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首页> 外文期刊>Life sciences >Interactions of nanoparticles bearing heparin or dextran covalently bound to poly(methyl methacrylate) with the complement system.
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Interactions of nanoparticles bearing heparin or dextran covalently bound to poly(methyl methacrylate) with the complement system.

机译：带有肝素或葡聚糖的纳米颗粒与补体系统的共价键与聚甲基丙烯酸甲酯的相互作用。

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摘要

The efficient uptake of injected nanoparticles by cells of the mononuclear phagocyte system (MPS) limits the development of long-circulating colloidal drug carriers. The complement system plays a major role in the opsonization and recognition processes of foreign materials. Since heparin is an inhibitor of complement activation, nanoparticles bearing heparin covalently bound to poly(methyl methacrylate) (PMMA) have been prepared and their interactions with complement evaluated. The particles retained the complement-inhibiting properties of soluble heparin. Nanoparticles bearing covalently bound dextran instead of heparin were weak activators of complement as compared with crosslinked dextran (Sephadex) or bare PMMA nanoparticles. In addition to the specific activity of bound heparin, the protective effect of both polysaccharides is hypothesized to be due to the presence of a dense brush-like layer on the surface of the particles. Such properties are expected to reduce the uptake by MPS in vivo.
机译：单核吞噬细胞系统（MPS）的细胞对摄入的纳米颗粒的有效吸收限制了长循环胶体药物载体的发展。补体系统在异物的调理和识别过程中起主要作用。由于肝素是补体激活的抑制剂，因此已经制备了带有肝素共价键合到聚甲基丙烯酸甲酯（PMMA）的纳米颗粒，并评估了它们与补体的相互作用。颗粒保留了可溶性肝素的补体抑制特性。与交联的葡聚糖（Sephadex）或裸露的PMMA纳米粒子相比，带有共价结合葡聚糖而不是肝素的纳米粒子是补体的弱激活剂。除了结合的肝素的特定活性外，两种多糖的保护作用被认为是由于在颗粒表面上存在致密的刷状层所致。预期此类性质将减少体内MPS的吸收。

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