Effects of an endothelin ET(A)-receptor antagonist, S-0139, on cerebral vasospasm and behavioral changes in dogs intracisternally administered endothelin-1.

Sato S; Yonetani Y; Fujimoto M; Kita T; Kubo K; Nakashima T

首页> 外文期刊>Life sciences >Effects of an endothelin ET(A)-receptor antagonist, S-0139, on cerebral vasospasm and behavioral changes in dogs intracisternally administered endothelin-1.

【24h】

Effects of an endothelin ET(A)-receptor antagonist, S-0139, on cerebral vasospasm and behavioral changes in dogs intracisternally administered endothelin-1.

机译：内皮素ET（A）受体拮抗剂S-0139对脑池痉挛内施用内皮素-1的狗的脑血管痉挛和行为变化的影响。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The effects of an endothelin ET(A)-receptor selective antagonist, S-0139, were examined using dogs given endothelin-1 (ET-1) into the subarachnoid space. ET-1 at 40 pmol apparently constricted the basilar artery in anesthetized dogs and caused various grades of ataxia, facial clonus, nystagmus and other features in conscious dogs, partially mimicking those which have been reported for conscious rats. S-0139 could completely inhibit both the vasoconstriction and behavioral changes. It could also alleviate the behavioral changes caused by ET-1 in conscious dogs when given after the severe ataxia. We concluded that ET-1 in the subarachnoid space produces behavioral changes via endothelin ET(A)-receptor mediation similar to its cerebral vasoconstricting action, at least, in dogs.

机译：使用给予内皮素-1（ET-1）进入蛛网膜下腔的狗检查了内皮素ET（A）-受体选择性拮抗剂S-0139的作用。 40 pmol的ET-1明显收缩了麻醉犬的基底动脉，并导致清醒犬的各种程度的共济失调，面部阵挛，眼球震颤和其他特征，部分模仿了已有清醒大鼠的报道。 S-0139可以完全抑制血管收缩和行为改变。重度共济失调后给予清醒犬，它还可以缓解由ET-1引起的行为改变。我们得出的结论是，至少在狗中，蛛网膜下腔中的ET-1通过内皮素ET（A）-受体介导产生类似于其脑血管收缩作用的行为变化。

著录项

来源
《Life sciences》 |1998年第13期|共7页
作者
Sato S; Yonetani Y; Fujimoto M; Kita T; Kubo K; Nakashima T;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类生命的起源;生命科学总论;
关键词
Behavior; Animal; Endothelin-1; Ischemic Attack; Transient drug therapy; 行为; 动物; 内皮缩血管肽-1; 齐墩果酸; 受体; 内皮缩血管肽;

机译：Behavior;Animal;Endothelin-1;Ischemic Attack;Transient drug therapy;行为;动物;内皮缩血管肽-1;齐墩果酸;受体;内皮缩血管肽;

相似文献

外文文献
中文文献
专利

1. Effects of an endothelin ET(A)-receptor antagonist, S-0139, on cerebral vasospasm and behavioral changes in dogs intracisternally administered endothelin-1. [J] . Sato S, Yonetani Y, Fujimoto M, Life sciences . 1998,第13期

机译：内皮素ET（A）受体拮抗剂S-0139对脑池痉挛内施用内皮素-1的狗的脑血管痉挛和行为变化的影响。
2. Systemic administration of the endothelin-A receptor antagonist TBC 11251 attenuates cerebral vasospasm after experimental subarachnoid hemorrhage: dose study and review of endothelin-based therapies in the literature on cerebral vasospasm. [J] . Wanebo JE, Arthur AS, Louis HG, Neurosurgery . 1998,第6期

机译：全身施用内皮素A受体拮抗剂TBC 11251可减轻实验性蛛网膜下腔出血后的脑血管痉挛：有关脑血管痉挛文献中基于内皮素的疗法的剂量研究和综述。
3. Studies of the antagonistic effect of BQ-123 on cerebral vasospasm induced by intracisternal injection of endothelin-1 and subarachnoid hemorrhage [J] . 王向宇, 陈长才, 李铁林, 中国人民解放军军医大学学报：英文版 . 1997,第002期

机译：BQ-123对内皮素-1和蛛网膜下腔出血脑血管痉挛对脑血管痉挛的拮抗作用研究
4. Discovery of a novel series of pseudo-peptide endothelin receptor antagonists: modifications of a tripeptide analogue [C] . Jun-Jun Dong, Han Han, Ping Wu, Chinese Peptide Symposium . 2005

机译：发现一种新型伪肽内皮受体拮抗剂的新型系列：三肽类似物的修饰
5. Differing effects of vasopressin on regional cerebral blood flow of dogs following intracisternal vs. intra-arterial administration [D] . Tsugane Shinichiro, Suzuki Yoshio, Kano Takahisa, 1994

机译：血管加压素对脑池内和动脉内给药后狗局部脑血流的不同作用
6. Prolonged pharmacodynamic effects of S-0139 an intravenously administered endothelin A (ETA) antagonist in the human forearm blood flow model [O] . Martin W Lunnon, Sharon M L Wallace, Joanne E Palmer, 2010

机译：静脉注射内皮素A（ETA）拮抗剂S-0139在人前臂血流模型中的药效延长
7. Prolonged pharmacodynamic effects of S-0139, an intravenously administered endothelin A (ETA) antagonist, in the human forearm blood flow model [O] . Lunnon, Martin W, Wallace, Sharon M L, Palmer, Joanne E, 2010

机译：静脉注射内皮素A（ETA）拮抗剂S-0139在人前臂血流模型中的药效延长

Effects of an endothelin ET(A)-receptor antagonist, S-0139, on cerebral vasospasm and behavioral changes in dogs intracisternally administered endothelin-1.

摘要

著录项

相似文献

相关主题

期刊订阅