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首页> 外文期刊>Life sciences >Increased endogenous nitric oxide synthase inhibitor in patients with congestive heart failure.
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Increased endogenous nitric oxide synthase inhibitor in patients with congestive heart failure.

机译：充血性心力衰竭患者内源性一氧化氮合酶抑制剂增加。

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Nitric oxide (NO) plays a role in controlling vascular tone and regulates the contractile properties of cardiac myocytes. Patients with heart failure exhibit high plasma levels of nitriteitrate (NOx), a stable metabolite of NO, and of cytokines such as tumor necrosis factor-alpha, a potent inducer of NO synthase. An increase in inducible NO synthase activity has been found in cardiac tissue from patients with dilated cardiomyopathy. These findings raise the possibility that local or systemic overproduction of NO induced by cytokines exerts a chronic negative inotropic effect on the myocardium and may have detrimental effects on systemic hemodynamics in patients with heart failure. Plasma levels of NG,NG-dimethylarginine (asymmetric dimethylarginine; ADMA), a circulating endogenous NO synthase inhibitor, were measured in control subjects and patients with valvular, hypertensive, or ischemic heart diseases or idiopathic cardiomyopathy. The plasma levels of NOx and ADMA were assessed by high performance liquid chromatography. The plasma levels of NOx and ADMA were significantly elevated in patients with heart failure. Both NOx and ADMA were positively correlated with New York Heart Association functional class. There was a significant inverse correlation between plasma NOx and ejection fraction, as estimated by echocardiography. A significant relationship between plasma NOx and ADMA was found only in patients with moderate to severe heart failure (r=0.41, p=0.01). Findings suggest a compensatory role of a circulating endogenous NO synthase inhibitor against induced NO synthase activity in patients with heart failure.
机译：一氧化氮（NO）在控制血管紧张度和调节心肌细胞的收缩特性中发挥作用。心力衰竭患者表现出高水平的血浆亚硝酸盐/硝酸盐（NOx），稳定的NO代谢物和细胞因子，例如肿瘤坏死因子-α（NO合酶的有效诱导剂）。在扩张型心肌病患者的心脏组织中发现诱导型NO合酶活性增加。这些发现增加了由细胞因子诱导的局部或全身性NO过量产生对心肌的慢性负性肌力作用并对心力衰竭患者的全身血流动力学产生不利影响的可能性。在对照组和患有瓣膜病，高血压或缺血性心脏病或特发性心肌病的患者中测量了血浆中循环内源性NO合酶抑制剂NG，NG-二甲基精氨酸（不对称的二甲基精氨酸; ADMA）的水平。通过高效液相色谱法评估NOx和ADMA的血浆水平。心力衰竭患者的血浆NOx和ADMA水平显着升高。 NOx和ADMA均与纽约心脏协会功能类别正相关。超声心动图估计血浆NOx与射血分数之间存在显着的负相关。仅在中度至重度心力衰竭患者中发现血浆NOx与ADMA之间存在显着相关性（r = 0.41，p = 0.01）。研究结果表明，循环性内源性NO合酶抑制剂对心力衰竭患者诱导的NO合酶活性具有补偿作用。

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