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首页> 外文期刊>Life sciences >Delta-9-tetrahydrocannabinol (THC) fails to stimulate consumption of a highly palatable food in the rat.
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Delta-9-tetrahydrocannabinol (THC) fails to stimulate consumption of a highly palatable food in the rat.

机译：Delta-9-四氢大麻酚（THC）不能刺激大鼠食用高口感的食物。

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摘要

THC is the active chemical component in marijuana. In humans, it is known to cause acute sedation, alterations of cognition, and to stimulate appetite. The goal of this study was to determine if THC would produce acute stimulation of the consumption of a highly-palatable food item in the rat. Separate groups of rats were administered THC (1.0 or 2.0 mg/kg) either 30, 60, or 120 min or saline 30 min prior to being placed in the presence of a highly palatable food (Nilla Wafers soaked in water). Spontaneous exploration decreased at the 2.0 mg/kg dose of THC at the 60 min time point. The amount of food eaten was not significantly changed at either dose. These results do not support the hypothesis that THC causes acute appetite stimulation in the rat. However, some other non-specific effect of THC that indirectly reduced food consumption without directly acting upon appetite is a possible explanation that cannot be presently excluded, and that will need to be assessed in future studies.
机译：THC是大麻中的活性化学成分。在人类中，已知引起急性镇静，认知改变和刺激食欲。这项研究的目的是确定四氢大麻酚是否会对大鼠食用高口感的食物产生刺激性刺激。在放置于高度可口的食物（Nilla Wafers浸在水中）中之前，分别给大鼠的30、60或120分钟或生理盐水30分钟，60分钟或120分钟施用THC（1.0或2.0 mg / kg）。在60分钟的时间点，以2.0 mg / kg的四氢大麻酚的自发探索作用降低。两种剂量下食用的食物量均无明显变化。这些结果不支持THC引起大鼠急性食欲刺激的假说。但是，四氢大麻酚的其他一些非特异性作用，即在不直接影响食欲的情况下间接减少了食物消耗，这是目前无法排除的可能解释，需要在以后的研究中进行评估。

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