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GABA(A)-receptor assembly in vivo: lessons from subunit mutant mice.

机译:体内GABA(A)受体组装:亚基突变小鼠的经验教训。

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摘要

The rules governing the assembly of GABA(A) receptors in vivo were assessed in subunit mutant mice. The transcription of individual subunit genes was regulated independently. The lack of a particular subunit did not result in a molecular rescue by an enhanced transcription of other subunits. In addition, the availability of an alpha- and beta-subunit was essential for receptor formation. Finally, highly selective recognition processes directed the subcellular targeting of receptors. The loss of a particular receptor subtype (alpha5) did not lead to a subcellular redistribution of the remaining subtype (alpha2) present in the same cell.
机译:在亚单位突变小鼠中评估了体内GABA(A)受体装配的规则。单个亚基基因的转录是独立调节的。缺少特定亚基不会通过其他亚基的转录增强而导致分子拯救。另外,α-和β-亚基的可用性对于受体形成至关重要。最后,高度选择性的识别过程指导受体的亚细胞靶向。特定受体亚型(alpha5)的丧失并不会导致同一细胞中剩余亚型(alpha2)的亚细胞再分布。

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