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首页> 外文期刊>Cell biology international. >Cancer: A matter of life cycle?
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Cancer: A matter of life cycle?

机译：癌症：生命周期问题？

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In the last decade, the concept of "cancer stem cells" has emerged, recognised by the fact that only a small fraction of tumour cells appears to retain the stem cell properties of self-renewal and unlimited proliferation. At the same time, it is well known that cancer is an age-related disease developing at the limit of proliferating cell senescence. The apparent need to link senescence and the capacity for self-renewal has lead some authors to suggest that cancers develop from amongst senescing stem cells. However, an alternative solution has recently been proffered by Sundaram M, Guernsey DL, Rajaraman MM, Rajaraman R [Neosis: a novel type of cell division in cancer. Cancer Biol Ther 2004;3:207-18], who suggest that stemness may be a transient, cyclic property afforded by de-polyploidisation of senescing cells which have undergone polyploidisation. In this mini-review, we attempt to reconcile both of these views by the idea that cycling polyploidy intermitting senescence and rejuvenation may be features of a life cycle analogous to the life cycles of certain unicellular organisms. Furthermore, we suggest that mitotic catastrophe may represent a mechanism through which the cell can switch from the usual mitotic cell-cycle to this evolutionarily conserved life cycle. Intriguingly, some most recent data suggest that cell senescence may be reversible and that stem cells are tolerant to polyploidy caused by genotoxic stress.
机译：在过去的十年中，“癌症干细胞”的概念出现了，这是因为只有一小部分肿瘤细胞似乎保留了自我更新和无限增殖的干细胞特性。同时，众所周知，癌症是与年龄相关的疾病，其在细胞衰老增殖的极限处发展。将衰老与自我更新的能力联系在一起的明显需求已导致一些作者提出，癌症是从衰老的干细胞中发展而来的。然而，Sundaram M，Guernsey DL，Rajaraman MM，Rajaraman R [Neosis：癌症中一种新型的细胞分裂类型]最近提供了一种替代解决方案。 Cancer Biol Ther 2004; 3：207-18]，他们提出干性可能是经过多倍化的感觉细胞的去多倍体化所提供的一种短暂的循环特性。在本篇微型综述中，我们尝试通过使多倍体间歇性衰老和恢复活力可能是类似于某些单细胞生物生命周期的生命周期的特征来调和这两种观点。此外，我们建议，有丝分裂灾难可能代表了一种机制，通过该机制，细胞可以从通常的有丝分裂细胞周期转换为这种进化上保守的生命周期。有趣的是，一些最新数据表明，细胞衰老可能是可逆的，并且干细胞对遗传毒性胁迫引起的多倍体具有耐受性。

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