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首页> 外文期刊>Life sciences >Distribution of (14C)-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration.
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Distribution of (14C)-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration.

机译：口服后，（14C）-反白藜芦醇（一种化学防癌多酚）在小鼠组织中的分布。

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Trans-resveratrol, a phenolic compound present in wine, has been reported to be a potential cancer chemopreventive agent. However, although it has numerous biological activities in vitro, there are few data about its bioavailability and tissue distribution in vivo. The objectives of this study were to investigate the absorption and tissue distribution of 14C-trans-resveratrol following oral administration to mice. Male Balb/c mice were given a single oral dose of 14C-trans-resveratrol and were sacrificed at 1.5, 3 or 6 h postdose. The distribution of radioactivity in tissues was evaluated using whole-body autoradiography, quantitative organ-level determination and microautoradiography. In addition, identification of radioactive compounds in kidney and liver was done with high-performance liquid chromatography. Autoradiographic survey of mice sections as well as radioactivity quantification in various organs revealed a preferential fixation of 14C-trans-resveratrol in the organs and biological liquids of absorption and elimination (stomach, liver, kidney, intestine, bile, urine). Moreover, we show that 14C-trans-resveratrol derived radioactivity is able to penetrate the tissues of liver and kidney, a finding supported by microautoradiography. The presence of intact 14C-trans-resveratrol together with glucurono- and/or sulfoconjugates in these tissues was also shown. This study demonstrates that trans-resveratrol is bioavailable following oral administration and remains mostly in intact form. The results also suggest a wide range of target organs for cancer chemoprevention by wine polyphenols in humans.
机译：据报道，葡萄酒中存在的一种酚类化合物反式白藜芦醇是一种潜在的癌症化学预防剂。然而，尽管其在体外具有许多生物活性，但是关于其在体内的生物利用度和组织分布的数据很少。这项研究的目的是调查口服给小鼠后14 C-反式白藜芦醇的吸收和组织分布。给雄性Balb / c小鼠单次口服剂量的14C-反式-白藜芦醇，并在给药后1.5、3或6小时处死。使用全身放射自显影，定量器官水平测定和显微放射自显影技术评估组织中放射性的分布。另外，用高效液相色谱法鉴定了肾脏和肝脏中的放射性化合物。放射自显影的小鼠切片以及各个器官的放射性定量分析显示，14C-反白藜芦醇优先固定在器官和吸收和消除生物液体（胃，肝，肾，肠，胆汁，尿液）中。此外，我们显示14C-反式白藜芦醇衍生的放射性能够穿透肝脏和肾脏的组织，这一发现得到了微放射自显影技术的支持。还显示了在这些组织中完整的14C-反式白藜芦醇与葡萄糖醛酸-和/或磺基结合物的存在。这项研究表明，口服后反式白藜芦醇具有生物利用度，并且大部分保持完整。这些结果还表明，葡萄酒中的多酚类物质可预防人类癌症的多种靶器官。

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