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首页> 外文期刊>Life sciences >The effect of local nitric oxide synthase inhibition on the diameter of pulpal arteriole in dental bond material-induced vasodilation in rat.
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The effect of local nitric oxide synthase inhibition on the diameter of pulpal arteriole in dental bond material-induced vasodilation in rat.

机译：局部一氧化氮合酶抑制对牙合材料诱导的大鼠血管扩张中牙髓小动脉直径的影响。

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摘要

Local application of dental bond materials can cause pulpal vasodilation and hyperemia. Such local hemodynamic changes may be mediated by alterations in the levels of locally generated nitric oxide (NO). In different species systemic administration of NO synthase inhibitors leads to a decrease in pulpal blood flow. In contrast, the local administration of these inhibitors has not been tested yet. Therefore, the effect of locally blocked NO synthase on the internal diameter of rat pulpal arterioles under basal conditions and immediately after dental bond material application was studied by using vitalmicroscopic technique. The NO synthase blocker (L-NAME) was locally administered on a thinned dentine layer of the left lower incisor. L-NAME reduced the diameter of the pulpal arteriole both in basal and after bond material-induced hyperaemic conditions. These data suggest that the local formation of NO may have a significant role in the acute vasodilation induced by bond material application and also in maintenance of basal pulpal arteriolar tone.
机译：局部使用牙齿粘合材料可能导致牙髓血管扩张和充血。这种局部血液动力学变化可以通过局部产生的一氧化氮（NO）水平的改变来介导。在不同物种中，NO合酶抑制剂的全身性给药导致牙髓血流量减少。相比之下，尚未测试这些抑制剂的局部给药。因此，通过生命显微镜技术研究了在基础条件下以及在牙科粘结材料施用后局部阻断的NO合酶对大鼠牙髓小动脉内径的影响。 NO合酶阻滞剂（L-NAME）局部施用于左下门牙的薄齿质层上。 L-NAME在基底和黏结物质诱导的充血条件下均降低了牙髓小动脉的直径。这些数据表明，NO的局部形成可能在粘结材料应用引起的急性血管舒张中以及在维持基底牙髓小动脉张力中起重要作用。

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