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首页> 外文期刊>Life sciences >EFFECTS OF HALOTHANE AND ISOFLURANE ON RAT VENTRICULAR ACTION POTENTIALS RECORDED IN SITU
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EFFECTS OF HALOTHANE AND ISOFLURANE ON RAT VENTRICULAR ACTION POTENTIALS RECORDED IN SITU

机译：卤代烷和异氟烷对原位记录的大鼠心室动作电位的影响

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The effects of halothane and isoflurane on ventricular intracellular action potentials recorded in situ in pentobarbital anesthetized rats were studied. Halothane (0.5, 1 and 2 vol.%) and isoflurane (0.75, 1.5 and 3 vol.%) did not have identical effects on rat epicardial action potentials recorded by floating microelectrodes. However, over the concentration range tested, both anesthetics reduced blood pressure and heart rate to a similar extent. Isoflurane did not effect the maximum rate of rise of the action potential or action potential amplitude. However, 3 vol.% isoflurane reduced the resting membrane potential from -72+/-2 to -65+/-3 mV (mean+/-SEM, p<0.05) while the highest concentration of halothane had no effect. Halothane (2 vol.%) reduced action potential amplitude from 74+/-4 to 65+/-3 mV (p<0.05) and reduced the maximum rise rate of the action potential from 175+/-21 to 133+/-8 V/s (p<0.05). Both isoflurane and halothane prolonged action potential duration at 10, 25 and 50% repolarization while only halothane significantly shortened action potential duration at 75% repolarization. Thus the effects of halothane and isoflurane on ventricular transmembrane action potentials were similar, but not identical. The relevance of such observations to the antiarrhythmic actions of halothane, but not isoflurane, in this species is not clear. [References: 37]
机译：研究了氟烷和异氟烷对戊巴比妥麻醉大鼠原位记录的心室细胞内动作电位的影响。氟烷（0.5％，1％和2％（体积））和异氟烷（0.75％，1.5％和3％（体积））对漂浮微电极记录的大鼠心外膜动作电位没有相同的作用。但是，在所测试的浓度范围内，两种麻醉剂均以相似的程度降低了血压和心率。异氟烷不会影响动作电位或动作电位振幅的最大上升速率。然而，3％（体积）的异氟烷使静息膜电位从-72 +/- 2降低到-65 +/- 3mV（平均值+/- SEM，p <0.05），而氟烷的最高浓度没有影响。氟烷（2体积％）将动作电位振幅从74 +/- 4降低到65 +/- 3 mV（p <0.05），并将动作电位的最大上升速率从175 +/- 21降低到133 +/- 8 V / s（p <0.05）。异氟烷和氟烷都延长了10、25和50％复极化时的动作电位持续时间，而只有氟烷显着缩短了75％复极化时的动作电位持续时间。因此，氟烷和异氟烷对心室跨膜动作电位的作用相似，但不完全相同。此类观察与氟烷的抗心律失常作用有关，但与异氟烷无关。 [参考：37]

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