• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >EFFECTS OF BRADYKININ ON THE INTRACELLULAR CALCIUM CONCENTRATION OF PANCREATIC ACINAR AR42J CELLS
【24h】

EFFECTS OF BRADYKININ ON THE INTRACELLULAR CALCIUM CONCENTRATION OF PANCREATIC ACINAR AR42J CELLS

机译：缓激肽对胰腺癌AR42J细胞内钙离子浓度的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We examined the effects of bradykinin (BK) on the intracellular free calcium concentration ([Ca2+](i)) in rat pancreatic acinar AR42J cells. BK induced a dose-dependent rise in [Ca+2](i) in AR42J cells between the concentrations of 10(-12) M and 10(-7) M. The BK-evoked response was not affected by the presence of Co2+ Or the absence of extracellular calcium. This response was suppressed by neomycin or the B-2 antagonist, but not by the B-1 antagonist. The response was also attenuated by treatment with dexamethasone. These results suggest that BK increases [Ca2+](i) through the B-2 receptors by promoting the phosphatidyl inositol turn-over and that, in the process of azaserine-induced undifferentiation, the pancreatic acinar cells strongly express the BK receptors. [References: 19]
机译：我们检查了缓激肽（BK）对大鼠胰腺腺泡AR42J细胞内细胞内游离钙浓度（[Ca2 +]（i））的影响。 BK诱导AR42J细胞中[Ca + 2]（i）在10（-12）M和10（-7）M浓度之间呈剂量依赖性上升。BK诱发的反应不受Co2 +的存在的影响或细胞外钙缺乏。该反应被新霉素或B-2拮抗剂抑制，但未被B-1拮抗剂抑制。地塞米松治疗也减弱了反应。这些结果表明，BK通过促进磷脂酰肌醇的转变而通过B-2受体增加[Ca2 +]（i），并且在氮杂酶诱导的未分化过程中，胰腺腺泡细胞强烈表达BK受体。 [参考：19]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号