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首页> 外文期刊>Life sciences >ROLE OF NOREPINEPHRINE IN SUPPRESSED IGG PRODUCTION IN EPILEPSY-PRONE MICE
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ROLE OF NOREPINEPHRINE IN SUPPRESSED IGG PRODUCTION IN EPILEPSY-PRONE MICE

机译：去甲肾上腺素在抑制癫痫小鼠IGG生产中的作用

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The responses of two substrains of Balb/c mice (Epilepsy Prone and Epilepsy Resistant) to immunization with sheep red blood cells (SRBC) were examined to determine whether chronic neurochemical differences between the two strains could influence B cell function. Anti;SRBC IgG production in the Epilepsy Prone (EP) strain was reduced relative to the Epilepsy Resistant (ER) strain, while anti-SRBC IgM production was unaffected. No differences were found in ih vitro antibody (Ab) production or T lymphocyte function between the EP and ER strains, suggesting that in vivo conditions rather than an intrinsic cellular defect are responsible for reduced IgG production by EP mice. Basal splenic norepinephrine (NE) levels were significantly higher in EP mice than those in ER mice, and remained significantly higher following immunization. ER mice treated with the beta(2) adrenergic agonist terbutaline on days 4, 5 and 6 after immunization produced significantly lower numbers of IgG PFC than did saline treated controls. Addition of NE during later stages of in vitro immunization suppressed both anti-SRBC IgM and IgG production by splenic lymphocytes from Balb/c mice, and NE was found to decrease IFN gamma production. These observations suggest that dysregulation of splenic NE can have an impact on the immune response. [References: 48]
机译：检查了两种Balb / c小鼠亚型（易发癫痫和抗癫痫性）对绵羊红细胞（SRBC）免疫的反应，以确定这两种株之间的慢性神经化学差异是否会影响B细胞功能。相对于抗癫痫药（ER）菌株，抗癫痫药（EP）菌株的抗; SRBC IgG产量降低，而抗SRBC IgM的产量不受影响。 EP和ER菌株之间的体外抗体（Ab）产生或T淋巴细胞功能均未发现差异，表明体内条件而非内在的细胞缺陷是造成EP小鼠IgG产生减少的原因。 EP小鼠的基础脾脏去甲肾上腺素（NE）水平显着高于ER小鼠，并且在免疫后仍显着更高。免疫后第4天，第5天和第6天用β（2）肾上腺素能激动剂特布他林治疗的ER小鼠产生的IgG PFC的数量明显低于生理盐水对照组。在体外免疫后期添加NE抑制了Balb / c小鼠脾淋巴细胞的抗SRBC IgM和IgG产生，并且发现NE降低了IFNγ的产生。这些观察结果表明脾脏NE的失调可影响免疫应答。 [参考：48]

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