首页> 外文期刊>Life sciences >AUTORADIOGRAPHIC DISTRIBUTION AND PHYSIOLOGICAL REGULATION OF 2-[I-123]IODOMELATONIN BINDING IN RAT EPIDIDYMIS
【24h】

AUTORADIOGRAPHIC DISTRIBUTION AND PHYSIOLOGICAL REGULATION OF 2-[I-123]IODOMELATONIN BINDING IN RAT EPIDIDYMIS

机译:大鼠脑脊液中2- [I-123]降钙素结合的放射自显影及生理调节

获取原文
获取原文并翻译 | 示例
           

摘要

Autoradiographic study was conducted to localize 2-[I-125]iodomelatonin binding in the rat epididymis. In the peripubertal (6 weeks old), postpubertal (8 weeks old) and adult (3 months old) rats, intense specific 2-[I-125]iodomelatonin labelling of the corpus epididymidis was observed. The intensity of 2-[I-125]iodomelatonin binding in the distal epididymal segment was significantly decreased in orchidectomized rats but the effect could be reversed with testosterone replacement. The intensity of 2-[I-125]iodomelatonin binding in the distal rat epididymal segment did not show any diurnal rhythmicity when mid-light period and mid-dark period levels were compared, and was unaffected by constant lighting. Our data suggest androgen-dependent expression of 2-[I-125]iodomelatonin binding sites, independent of light-induced changes in circulating melatonin, in the rat corpus epididymidis. A novel role of melatonin and its receptor in the regulation of the functions of rat corpus epididymidis is strongly implicated. [References: 50]
机译:进行放射自显影研究以定位2-附睾酮在大鼠附睾中的结合。在青春期周龄(6周龄),青春期后(8周龄)和成年(3个月龄)大鼠中,观察到附睾dy体的强烈特异性2- [I-125] iodomelatonin标记。在切除睾丸的大鼠中,远端附睾节段中2- [I-125]碘降钙素的结合强度显着降低,但睾丸激素替代可以逆转这种作用。当比较中亮期和中暗期水平时,远侧大鼠附睾节段中2- [I-125]碘酮的结合强度没有显示任何昼夜节律,并且不受恒定光照的影响。我们的数据表明,大鼠附睾中2- [I-125] iodomelatonin结合位点的雄激素依赖性表达,与光诱导的循环褪黑素的变化无关。强烈暗示褪黑素及其受体在大鼠附睾功能的调节中的新作用。 [参考:50]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号