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首页> 外文期刊>Cell biology international. >Melanomas display increased cytoprotection to hypericin-mediated cytotoxicity through the induction of autophagy.
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Melanomas display increased cytoprotection to hypericin-mediated cytotoxicity through the induction of autophagy.

机译：黑色素瘤通过诱导自噬而显示出对金丝桃素介导的细胞毒性增强的细胞保护作用。

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摘要

Photodynamic therapy (PDT) as a regime for melanoma is of limited success due to factors such as the efficacy of the photosensitizer used, penetration depth and the presence of pigment. We characterised a pigmented and an unpigmented melanoma cell line with respect to their phenotypes. Cell viability was assessed after exposure to hypericin, a UVA-activated photosensitizer. Exposure to 3 microM activated hypericin induced a cytoprotective (autophagic) response from both cell lines. However, the pigmented cells accumulated a large amount of glycogen in their cytoplasm. We hypothesise that the treatment induces an initial cytoprotective response through autophagy, but with increased stress results in a different mode of cell death in pigmented melanoma cells from unpigmented cells. These results indicate that hypericin-PDT could be an adjuvant therapy for melanoma.
机译：由于诸如所使用的光敏剂的功效，渗透深度和色素的存在等因素，光动力疗法（PDT）作为黑色素瘤的治疗方案取得的成功有限。我们表征了有色和无色黑色素瘤细胞系的表型。暴露于金丝桃素（一种UVA活化的光敏剂）后，评估细胞活力。暴露于3 microM激活的金丝桃素诱导了两种细胞系的细胞保护性（自噬）反应。但是，有色细胞在其细胞质中积累了大量糖原。我们假设该治疗通过自噬诱导了初始的细胞保护反应，但随着压力的增加，有色黑色素瘤细胞与未色素沉着细胞的细胞死亡方式不同。这些结果表明金丝桃素-PDT可能是黑色素瘤的辅助治疗方法。

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