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首页> 外文期刊>Life sciences >Alzheimer's disease, the nematode Caenorhabditis elegans, and ginkgo biloba leaf extract.
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Alzheimer's disease, the nematode Caenorhabditis elegans, and ginkgo biloba leaf extract.

机译：阿尔茨海默氏病，线虫秀丽隐杆线虫和银杏叶提取物。

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摘要

Alzheimer's disease (AD) is affecting larger and larger proportions of our population as lifespan increases. Thus, the means to prevent or reduce the rate of this disorder is a high priority for medical research. A standardized extract of Ginkgo biloba leaves EGb 761 is a popular dietary supplement taken by the general public to enhance mental focus and by the elderly to delay onset of age-related loss of cognitive function. EGb 761 has been used for treatment of certain cerebral dysfunctions and dementias associated with aging and AD. Substantial evidence indicates that EGb 761 has neuroprotective effects. But, mechanisms of action of the components of the extract are, unfortunately, poorly understood. Research in my laboratory focuses on understanding mechanisms of action of the components of the herbal extract EGb 761 in protection against Alzheimer's disease. We have demonstrated that EGb 761 inhibited amyloid beta aggregation in vitro and attenuates reactive oxidative species (ROS) in a model organism - the round worm Caenorhabditis elegans. Furthermore, EGb 761 eased its toxicity in the transgenic C. elegans. We also found that only a certain size of the amyloid beta aggregates is toxic to the worms. These findings suggest that EGb 761 has a clear therapeutic potential for prevention and/or treatment of AD. A better understanding of the mechanisms of neuroprotection by EGb 761 will be important for designing therapeutic strategies, for basic understanding of the underlying neurodegenerative processes, and for a better understanding of the effectiveness and complexity of this herbal medicine.
机译：随着寿命的延长，阿尔茨海默氏病（AD）正在影响着越来越多的人口。因此，预防或降低这种疾病的发生率的方法是医学研究的重中之重。银杏叶EGb 761的标准提取物是一种流行的膳食补充剂，已被公众广泛采用，以增强精神注意力，老年人则可以延缓与年龄有关的认知功能丧失的发作。 EGb 761已用于治疗某些与衰老和AD相关的脑功能障碍和痴呆症。大量证据表明，EGB 761具有神经保护作用。但是，不幸的是，人们对提取物成分的作用机理了解甚少。我实验室的研究重点是了解草药提取物EGb 761的成分在预防阿尔茨海默氏病中的作用机理。我们已经证明，EGB 761在体外抑制淀粉样蛋白β聚集并减弱模型生物-线虫秀丽隐杆线虫中的反应性氧化物质（ROS）。此外，EGB 761减轻了其在转基因秀丽隐杆线虫中的毒性。我们还发现，只有一定大小的淀粉样β聚集体对蠕虫有毒。这些发现表明，EGb 761对于AD的预防和/或治疗具有明显的治疗潜力。更好地了解EGb 761的神经保护机制对于设计治疗策略，基本了解潜在的神经退行性过程以及更好地了解这种草药的有效性和复杂性至关重要。

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