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首页> 外文期刊>Life sciences >AMELIORATING EFFECTS OF HISTIDINE ON SCOPOLAMINE-INDUCED LEARNING DEFICITS USING AN ELEVATED PLUS-MAZE TEST IN MICE
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AMELIORATING EFFECTS OF HISTIDINE ON SCOPOLAMINE-INDUCED LEARNING DEFICITS USING AN ELEVATED PLUS-MAZE TEST IN MICE

机译：组胺法对小鼠组胺改善大MEL胺诱导的学习障碍的改善作用

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We investigated the effects of histidine on scopolamine-induced learning deficits in the elevated plus-maze test in mice. In this test, transfer latency (TL), the time mice took to move from the open arm to the enclosed arm, was used as an index of learning and memory. Intraperitoneal administration of scopolamine (0.5 mg/kg) prolonged the TL on day 2 compared with that in the saline-treated group. Histidine loading (500, 800 and 1600 mg/kg) reversed the prolongation of the TL induced by scopolamine. This ameliorating effect of histidine was abolished by alpha-fluoromethylhistidine, an inhibitor of histidine decarboxylase, suggesting that histidine itself has no such ameliorating effect. Moreover, the ameliorating effect of histidine was antagonized by a histamine H-1 receptor antagonist, pyrilamine. However, zolantidine, a histamine H-2 receptor antagonist, showed no antagonism of the effect of histidine. Thus, histamine, a decarboxylated product of histidine, elicited an ameliorating effect on scopolamine-induced learning deficit via histamine H-1 receptors in mice. These findings clearly indicated that there is a close relationship between histaminergic and cholinergic systems in the brain, and that histamine may play certain important roles in learning and memory. [References: 45]
机译：我们在小鼠的高迷迷宫试验中研究了组氨酸对东pol碱诱导的学习缺陷的影响。在这项测试中，转移潜伏期（TL）是小鼠从张开的手臂移到封闭的手臂所花费的时间，被用作学习和记忆的指标。与盐水治疗组相比，东pol碱（0.5 mg / kg）的腹膜内给药延长了第2天的TL。组氨酸负荷（500、800和1600 mg / kg）逆转了东pol碱诱导的TL延长。组氨酸的这种改善作用被组氨酸脱羧酶的抑制剂α-氟甲基组氨酸消除，表明组氨酸本身没有这种改善作用。此外，组胺H-1受体拮抗剂吡拉明拮抗组氨酸的改善作用。然而，组胺H-2受体拮抗剂佐洛替丁对组氨酸的作用没有拮抗作用。因此，组胺是一种组氨酸的脱羧产物，它通过组胺H-1受体对东pol碱引起的学习障碍有改善作用。这些发现清楚地表明，脑中组胺能和胆碱能系统之间存在密切关系，并且组胺可能在学习和记忆中起某些重要作用。 [参考：45]

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