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首页> 外文期刊>Life sciences >CENTRAL NERVOUS SYSTEM NORADRENERGIC AND DOPAMINERGIC TURNOVER IN RESPONSE TO ACUTE NEUROLEPTIC CHALLENGE
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CENTRAL NERVOUS SYSTEM NORADRENERGIC AND DOPAMINERGIC TURNOVER IN RESPONSE TO ACUTE NEUROLEPTIC CHALLENGE

机译：中枢神经系统去神经和多巴胺能反应对急性神经病的挑战

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The objective of this study was to obtain direct neurochemical measures of the central nervous system's response to a typical neuroleptic, haloperidol, in human subjects. Nine healthy volunteers participated in this study. Central nervous system neuronal activity was assessed by measuring the plasma concentration and overflow from the brain of dopamine, norepinephrine, and their lipophilic and acidic metabolites after acute intravenous administration of haloperidol. By combining bilateral internal jugular vein blood sampling with cerebral blood flow scans we were able to differentiate between cortical and subcortical responses to haloperidol. The central nervous system response to haloperidol administration displayed a degree of regional specificity. Dopamine release, estimated from the overflow of homovanillic and dihydroxyphenylacetic acids, was reduced in cortical but not subcortical brain regions. Norepinephrine turnover was increased in cortical and subcortical brain regions. The overflow of homovanillic acid from the brain into the internal jugular veins was not related quantitatively to the arterial plasma concentrations of the catecholamines examined, homovanillic and dihydroxyphenylacetic acids or prolactin. Measurements of catecholamines and their metabolites in arterial plasma gave little indication as to monoaminergic neuronal activity in the brain. [References: 42]
机译：这项研究的目的是获得对人类受试者中枢神经系统对典型抗精神病药氟哌啶醇的反应的直接神经化学测量。九名健康志愿者参加了这项研究。在急性静脉内注射氟哌啶醇后，通过测量血浆浓度和多巴胺，去甲肾上腺素以及它们的亲脂性和酸性代谢物的血浆浓度和脑溢流来评估中枢神经系统的神经元活性。通过将双侧颈内静脉血采样与脑血流扫描相结合，我们能够区分氟哌啶醇对皮质和皮质下的反应。对氟哌啶醇给药的中枢神经系统反应表现出一定程度的区域特异性。根据高香草酸和二羟基苯基乙酸的溢流估算，多巴胺的释放在皮层但不在皮层下的大脑区域减少。皮质和皮质下脑区域中去甲肾上腺素的转换增加。高香草酸从大脑溢出到颈内静脉与定量的儿茶酚胺，高香草酸和二羟苯基乙酸或催乳素的动脉血浆浓度没有定量关系。动脉血浆中儿茶酚胺及其代谢产物的测定几乎不能说明大脑中单胺能神经元的活动。 [参考：42]

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