• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon 'Grosso' essential oil.
【24h】

Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon 'Grosso' essential oil.

机译：吸入和口服Lavandula hybrida Reverchon“ Grosso”精油的抗伤害和胃保护作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this study the antinociceptive and the gastroprotective effects of orally administered or inhaled Lavandula hybrida Reverchon "Grosso" essential oil, and its principal constituents linalool and linalyl acetate were evaluated in rodents. Either when orally administered (100 mg/kg) or inhaled for 60 min lavender essential oil significantly reduced the acetic acid-writhing response in a naloxone-sensitive manner. In the hot plate test, analgesic activity observed after oil inhalation was inhibited by naloxone, atropine, mecamylamine pretreatment suggesting the involvement of opioidergic as well as cholinergic pathways. Regardless of the administration route and the experimental model used both linalool and linalyl acetate did not produce significant analgesic response. Oral or inhalatory treatment with analgesic doses of essential oil did not affect mice spontaneous locomotor activity. Concerning the gastric effects, lavender oil, linalool and linalyl acetate oral administration protected against acuteethanol-induced gastric ulcers but did not prevent indomethacin-induced lesions indicating no interference with arachidonic acid metabolic cascade. In conclusion, besides this gastroprotection, lavender oil reveals an interesting analgesic activity mainly relevant after inhalation, at doses devoid of sedative side effect, suggesting the interest for potential application of this oil in aromatherapy.
机译：在这项研究中，在啮齿动物中评估了口服或吸入薰衣草Reverchon“ Grosso”精油及其主要成分芳樟醇和乙酸芳樟酯的镇痛和胃保护作用。口服（100 mg / kg）或吸入薰衣草精油60分钟，均以纳洛酮敏感的方式显着降低了醋酸扭曲反应。在热板试验中，纳洛酮，阿托品，美加明胺预处理抑制了吸油后的镇痛活性，表明阿片皮酸和胆碱能途径均参与其中。无论给药途径和使用的实验模型如何，芳樟醇和乙酸芳樟酯都不会产生明显的镇痛反应。镇痛剂量的精油经口或吸入治疗不会影响小鼠的自发运动能力。关于胃效应，口服薰衣草油，芳樟醇和乙酸芳樟酯可预防急性乙醇诱导的胃溃疡，但不能预防消炎痛诱导的损伤，表明不干扰花生四烯酸代谢级联反应。总之，除了这种胃保护作用外，薰衣草油还显示出一种有趣的止痛活性，主要在吸入后起作用，其剂量没有镇静副作用，这表明该油可能在芳香疗法中得到应用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号