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首页> 外文期刊>Life sciences >Intermittent nicotine administration modulates food intake in rats by acting on nicotine receptors localized to the brainstem
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Intermittent nicotine administration modulates food intake in rats by acting on nicotine receptors localized to the brainstem

机译：间歇性尼古丁给药通过作用于脑干局部的尼古丁受体来调节大鼠的食物摄入

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Previous studies have shown nicotine (NIC) administration leads to decreased food intake, while other investigations have reported that NIC stimulates c-Fos expression in the brainstem. Whether there is a causal relationship between NIC effects on ingestion and its effect on brainstem neurons is uncertain, however we hypothesized that blocking NIC action in the brainstem would prevent, to some extent, the hypophagic effects of NIC. In the present study, cannulas were placed in the fourth ventricle of rats. A dose of NIC or saline was injected i.p. in four equal injections during the dark phase for four days. At the start of the second day of injections the NIC receptor antagonist mecamylamine (MEC) or artificial cerebrospinal fluid (a-CSF) was infused intracerebroventricularly (i.c.v.). Thus, four experimental groups were examined: a-CSF + SAL; a-CSF + NIC; MEC + SAL; MEC + NIC. Meal patterns were recorded using a computerized system and water intake and body weight were measured daily. Peripheral NIC injections suppressed food intake by decreasing meal size, whereas infusion of the NTIC receptor antagonist MEC (4 mug) into the fourth ventricle blocked the NIC suppression of food intake. Moreover, the MEC effect was due primarily to an increase in dark phase meal size, which suggests neurons localized to the brainstem transmit NIC signals that regulate feeding behavior by affecting meal size. (C) 2004 Elsevier Inc. All rights reserved. [References: 57]
机译：先前的研究表明，尼古丁（NIC）的使用会导致食物摄入减少，而其他研究则报道，NIC会刺激脑干中的c-Fos表达。 NIC对摄入的影响与对脑干神经元的影响之间是否存在因果关系尚不确定，但是我们假设阻止脑干中的NIC作用将在一定程度上预防NIC的吞咽作用。在本研究中，套管被置于大鼠的第四脑室。腹膜内注射一定剂量的NIC或生理盐水。在黑暗阶段持续四天进行四次均等注射。在注射的第二天开始时，脑室内（i.c.v.）注射NIC受体拮抗剂美卡明胺（MEC）或人工脑脊髓液（a-CSF）。因此，检查了四个实验组：α-CSF+ SAL;α-CSF+ SAL;和α-CSF。 a-CSF + NIC; MEC + SAL; MEC + NIC。使用计算机系统记录膳食模式，并每天测量进水量和体重。外围NIC注射通过减少进餐量来抑制食物摄入，而将NTIC受体拮抗剂MEC（4杯）注入第四脑室则阻止了NIC抑制食物摄入。此外，MEC效应主要归因于黑暗阶段进餐量的增加，这表明位于脑干的神经元会传输NIC信号，从而通过影响进餐量来调节喂养行为。 （C）2004 Elsevier Inc.保留所有权利。 [参考：57]

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