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Cardiovascular and renal characteristics, and responses to acute volume expansion of a rat model of diabetic pregnancy

机译：糖尿病妊娠大鼠模型的心血管和肾脏特征以及对急性容量扩张的反应

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The objective of this study was to characterize the cardiovascular and renal alterations that occur during diabetic pregnancy, and to evaluate the effect of insulin treatment in 12-14 days pregnant diabetic rats. Four groups of female Sprague Dawley rats were studied: virgin control group (NP), pregnant control group (CP), diabetic pregnant group (DP), and diabetic pregnant group with insulin treatment (DPI). Systolic arterial pressure (SAP) was increased on day 12, whereas heart rate (HR) decreased starting with day 3 in DP group of rats. DP rats exhibited marked renal hypertrophy with greater kidney weight (wt) and kidney wt/body wt ratio. Insulin treatment normalized blood glucose (BG) concentration, SAP and HR, and prevented the increase in kidney wt/body wt ratio in DPI rats. At the time of the terminal acute experiment, acute saline volume expansion (VE, 5% body wt/30 min) significantly increased renal interstitial hydrostatic pressure (RIHP), urinary sodium excretion (UNaV) and urine flow rate (V) in all groups, but the increases (A) were significantly attenuated in both CP (1.7 +/- 0.2 mmHg, 12.0 +/- 1.5 muEq.min(-1) .g kidney wt(-1) and 76.2 +/- 10.9 mul.min(-1) .g kidney wt(-1) for DeltaRIHP, DeltaU(Na)V and DeltaV respectively) and DP (1.3 +/- 0.1 mmHg, 6.8 +/- 1.8 muEq.min(-1).g kidney wt(-1) and 32.3 +/- 9.3 mul.min(-1).g kidney wt(-1) for DeltaRIHP, DeltaU(Na)V and DeltaV respectively) group of rats as compared to NP (4.0 +/- 0.6 mmHg, 21.6 +/- 1.4 muEq.min(-1) .g kidney wt(-1) and 136.8 +/- 10.5 mul.min(-1).g kidney wt(-1) for DeltaRIHP, DeltaU(Na)V and DeltaV respectively) group of rats. Although RIHP response to VE was similar in DP and CP group of rats, the natriuretic and diuretic responses to VE were significantly lower in DP as compared to CP group of rats. Insulin treatment had no effect on RIHP response (DeltaRIHP = 1.5 +/- 0.3 mmHg), but restored most of the natriuretic (DeltaU(Na)V = 15.7 +/- 2.9 muEq.min(-1).g kidney wt(-1)) and diuretic (DeltaV = 100.2 +/- 19.3 mul.min(-1).g kidney wt(-1)) responses to VE in DPI as compared with CP group of rats. These data suggest that with VE, the restoration of the increase in UNaV and V with insulin treatment in diabetic pregnant rats is not mediated by changes in RIHP. (C) 2004 Elsevier Inc. All rights reserved.
机译：这项研究的目的是表征糖尿病妊娠期间发生的心血管和肾脏改变，并评估12-14天妊娠糖尿病大鼠中胰岛素治疗的效果。研究了四组雌性Sprague Dawley大鼠：原始对照组（NP），妊娠对照组（CP），糖尿病妊娠组（DP）和接受胰岛素治疗的糖尿病妊娠组（DPI）。 DP组大鼠从第3天开始，收缩压（SAP）升高，而心率（HR）从第3天开始降低。 DP大鼠表现出明显的肾脏肥大，具有更大的肾脏重量（wt）和肾脏wt / body wt比。胰岛素治疗可使DPI大鼠的血糖（BG）浓度，SAP和HR正常化，并阻止了肾脏wt / body wt比的增加。在终末急性试验时，所有组的急性盐水体积扩张（VE，5％体重/ 30分钟）显着增加了肾间质静水压（RIHP），尿钠排泄（UNaV）和尿流率（V） ，但两者的CP（1.7 +/- 0.2 mmHg，12.0 +/- 1.5 muEq.min（-1）.g肾脏wt（-1）和76.2 +/- 10.9 mul.min （-1）对于DeltaRIHP，DeltaU（Na）V和DeltaV分别为.g肾脏wt（-1）和DP（1.3 +/- 0.1 mmHg，6.8 +/- 1.8 muEq.min（-1）.g肾脏wt （-1）和DeltaRIHP，DeltaU（Na）V和DeltaV组的大鼠的肾脏wt（-1）和32.3 +/- 9.3 mul.min（-1）.g肾脏wt（-1）与NP（4.0 +/- 0.6 mmHg，21.6 +/- 1.4 muEq.min（-1）.g肾脏wt（-1）和136.8 +/- 10.5 mul.min（-1）.g肾脏wt（-1）用于DeltaRIHP，DeltaU（Na） V和DeltaV）组。尽管DP和CP组大鼠的RIHP对VE的反应相似，但与CP组大鼠相比，DP对VE的利尿和利尿反应明显降低。胰岛素治疗对RIHP反应无影响（DeltaRIHP = 1.5 +/- 0.3 mmHg），但恢复了大部分利钠尿（DeltaU（Na）V = 15.7 +/- 2.9 muEq.min（-1）.g肾脏wt（- 1））和利尿剂（DeltaV = 100.2 +/- 19.3 mul.min（-1）.g肾脏wt（-1））对DPI中的VE的反应与CP组的大鼠相比。这些数据表明，对于VE，在糖尿病妊娠大鼠中用胰岛素治疗恢复UNaV和V的增加不是由RIHP的改变介导的。 （C）2004 Elsevier Inc.保留所有权利。

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