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首页> 外文期刊>Life sciences >Pharmacokinetic behavior in plasma, cerebrospinal fluid and cerebral cortex after intranasal administration of hydrochloride meptazinol.
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Pharmacokinetic behavior in plasma, cerebrospinal fluid and cerebral cortex after intranasal administration of hydrochloride meptazinol.

机译：鼻内注射盐酸甲哌嗪醇后血浆，脑脊液和大脑皮质的药代动力学行为。

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摘要

The aim of this paper is to investigate the pharmacokinetic behavior of hydrochloride meptazinol (MEP) in plasma, cerebrospinal fluid (CSF) and cerebral cortex after intranasal administration (8 mg/kg) in male Sprague-Dawley rats. The pharmacokinetic study of intravenous administration (8 mg/kg) was also performed in rats. CSF and cerebral cortex samples were collected by serial CSF sampling and intracerebral microdialysis, respectively. The concentration of MEP in the biological samples was measured by high performance liquid chromatography (HPLC). It was determined that the absorption of MEP from the nasal cavity to systemic circulation was rapid and complete. The concentration-time profile showed a prolonged duration of MEP concentration in CSF and cortex following intranasal administration. The ratios of AUC values of intranasal to intravenous administrations were 0.96, 1.07 and 1.81 in plasma, CSF and cortex dialysate, respectively. In conclusion, intranasal administration of MEP is a promising alternative to traditional administration modes. Olfactory mucosa did not present intranasal MEP another pathway, in addition to systemic absorption, for transport to the brain.
机译：本文的目的是研究雄性Sprague-Dawley大鼠经鼻内给药（8 mg / kg）后，盐酸甲哌嗪醇（MEP）在血浆，脑脊液（CSF）和大脑皮层中的药代动力学行为。还在大鼠中进行了静脉内给药（8 mg / kg）的药代动力学研究。通过连续脑脊液采样和脑内微透析分别收集脑脊液和大脑皮层样本。通过高效液相色谱（HPLC）测量生物样品中的MEP浓度。已经确定，MEP从鼻腔到全身循环的吸收是快速而完整的。浓度-时间曲线显示鼻内给药后脑脊液和皮层中MEP浓度的持续时间延长。在血浆，CSF和皮质透析液中，鼻内给药与静脉内给药的AUC值之比分别为0.96、1.07和1.81。综上所述，鼻内给药的MEP是传统给药方式的有希望的替代方法。嗅粘膜除了全身吸收外，没有表现出鼻内MEP转运至大脑的另一种途径。

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