Translocation of Bax in rat hepatocytes cultured with ferric nitrilotriacetate

Zhou YJ; Chen HS; Sha BX; Yao DB; Shi JH; Ge XS; Li Y; Yi C

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Translocation of Bax in rat hepatocytes cultured with ferric nitrilotriacetate

机译：次氮基三乙酸铁培养的大鼠肝细胞中Bax的易位

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Hepatic fibrosis occurs after many years of iron overload in liver. An effective iron deposition model induced by ferric nitrilotriacetate (FeNTA) in cultured rat hepatocytes was assumed. It has been shown that treatment of rat hepatocytes with FeNTA lead to oxidative stress and hepatocyte apoptosis. Hepatocyte apoptosis can promote liver fibrosis. The mechanisms of hepatocyte apoptosis induced by FeNTA have not yet been fully elucidated. The present stud), demonstrated that FeNTA-induced hepatocyte apoptosis was related to Bax translocation, cytochrome c release, and caspase-3 activation. (c) 2005 Published by Elsevier Inc.

机译：肝中铁超载多年后，就会发生肝纤维化。假定由次氮基三乙酸铁（FeNTA）在培养的大鼠肝细胞中诱导了有效的铁沉积模型。已经显示用FeNTA处理大鼠肝细胞导致氧化应激和肝细胞凋亡。肝细胞凋亡可促进肝纤维化。 FeNTA诱导肝细胞凋亡的机制尚未完全阐明。本研究表明，FeNTA诱导的肝细胞凋亡与Bax易位，细胞色素c释放和caspase-3激活有关。（c）2005年由Elsevier Inc.发布。

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《Life sciences》 |2005年第24期|共10页
作者
Zhou YJ; Chen HS; Sha BX; Yao DB; Shi JH; Ge XS; Li Y; Yi C;
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正文语种 eng
中图分类生命的起源;
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hepatocyte; oxidative stress; Bax; cytochrome c; apoptosis; 17 beta-estradiol; ESTROGEN-RECEPTOR-BETA; OXYGEN SPECIES ROS; GROWTH-FACTOR; CYTOCHROME-C; APOPTOSIS; ESTRADIOL; DAMAGE; ANTIOXIDANTS; FIBROSIS; RELEASE;

机译：肝细胞;氧化应激;Bax;细胞色素c;细胞凋亡;17β-雌二醇;雌激素受体;氧物种ROS;生长因子;细胞色素C;凋亡;雌激素;损伤;抗氧化剂;纤维化;释放;

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1. Translocation of Bax in rat hepatocytes cultured with ferric nitrilotriacetate [J] . Zhou YJ, Chen HS, Sha BX, Life sciences . 2005,第24期

机译：次氮基三乙酸铁培养的大鼠肝细胞中Bax的易位
2. Endoplasmic reticulum stress and C/EBP homologous protein-induced Bax translocation are involved in angiotensin II-induced apoptosis in cultured neonatal rat cardiomyocytes [J] . ZouX.-J., YangL., YaoS.-L. Experimental Biology and Medicine: Journal of the Society for Experimental Biology and Medicine . 2012,第11期

机译：内质网应激和C / EBP同源蛋白诱导的Bax易位参与血管紧张素II诱导的新生大鼠心肌细胞凋亡
3. Impairment of glucokinase translocation in cultured hepatocytes from OLETF and GK rats, animal models of type 2 diabetes. [J] . Toyoda Y, Ito Y, Tanigawa K, Archives of histology and cytology. . 2000,第3期

机译：OLETF和GK大鼠（2型糖尿病动物模型）培养的肝细胞中葡萄糖激酶易位障碍。
4. Glycogen synthase kinase-3p facilitates cell apoptosis induced by high fluence low-power laser irradiation through acceleration of Bax translocation [C] . Lei Huang, Shengnan Wu, Da Xing Mechanisms for low-light therapy VI . 2011

机译：糖原合酶激酶3p通过促进Bax易位促进高通量低功率激光照射诱导的细胞凋亡
5. The activation of signaling pathways and the regulation of heme-oxygenase 1 and cytochrome P450 2E1 by ketone bodies in primary cultured rat hepatocytes. [D] . Abdelmegeed, Mohamed A. 2005

机译：酮体在原代培养的大鼠肝细胞中的信号传导途径的激活以及血红素加氧酶1和细胞色素P450 2E1的调节。
6. Astaxanthin ameliorates ferric nitrilotriacetate-induced renal oxidative injury in rats [O] . Yasumasa Okazaki, Shigeru Okada, Shinya Toyokuni 2017

机译：虾青素改善次氮基三乙酸铁诱导的大鼠肾脏氧化损伤
7. Ferric citrate uptake by cultured rat hepatocytes is inhibited in the presence of transferrin [O] . Ross M. Graham, Evan H. Morgan, Erica Baker 1998

机译：培养的大鼠肝细胞在转化素存在下培养的大鼠肝细胞的柠檬酸酯摄取
8. Comparative Toxicity of Cyclic Peptides and Depsipeptides in Cultured Rat Hepatocytes. [R] . Mereish, K. A., Solow, R., Singh, Y., 1989

机译：循环肽和缩酚酸肽在培养大鼠肝细胞中的比较毒性。

Translocation of Bax in rat hepatocytes cultured with ferric nitrilotriacetate

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