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首页> 外文期刊>Life sciences >Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity.
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Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity.

机译：植物精油的比较筛选：以苯基丙烷部分为抗血小板活性的基本核心。

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Essential oils extracted from different plants (Anthemis nobilis L., Artemisia dracunculus L., Cannabis sativa L., Cupressus sempervirens L., Cymbopogon citratus (DC.) Stapf., Curcuma longa L., Foeniculum vulgare L., Hypericum perforatum L., Hyssopus officinalis L., Mentha spicata L., Monarda didyma L., Ocimum basilicum L., Ocotea quixos Kosterm., Origanum vulgare L., Pinus nigra J.F. Arnold, Pinus silvestris L., Piper crassinervium Kunth., Rosmarinus officinalis L., Salvia officinalis L., Salvia sclarea L., Santolina chamaecyparissus L., Thymus vulgaris L., Zingiber officinaie L.) were screened in guinea pig and rat plasma in order to assess antiplatelet activity and inhibition of clot retraction. The oils were chemically analysed and a relationship between components and ability to affect hemostasis was evidenced. O. quixos, F. vulgaris, and A. dracunculus showed the highest antiplatelet activity against ADP, Arachidonic Acid and the Thromboxane A2 agonist U46619 (IC50, 4-132 microg ml(-1)), and a good ability to destabilize clot retraction (IC50, 19-180 microg ml(-1)). For these oils a significant correlation between antiplatelet potency and phenylpropanoids content (54-86%) was evidenced thus suggesting a key role for this moiety in the prevention of clot formation. These findings provide the rationale to take in account the antiplatelet activity in the pharmacological screening of natural products containing phenylpropanoids.
机译：从不同植物中提取的香精油（Anthemis nobilis L.，Artemisia dracunculus L.，Cannabis sativa L.，Cupressus sempervirens L.，Cymbopogon citratus（DC。）Stapf。，Curcuma longa L. ，Hyssopus officinalis L.，Mentha spicata L.，Monarda didyma L.，Ocimum basilicum L.，Ocotea quixos Kosterm。，Origanum vulgare L.，Pinus nigra JF Arnold，Pinus silvestris L.在豚鼠和大鼠血浆中筛选了丹参，丹参，丹参，桑托里纳chamaecyparissus，百里香，姜等，以评估其抗血小板活性和抑制血块回缩。对这些油进行了化学分析，并证明了成分与影响止血能力之间的关系。 O. quixos，F. vulgaris和A. dracunculus显示出最高的抗ADP，花生四烯酸和血栓烷A2激动剂U46619的抗血小板活性（IC50，4-132 microg ml（-1）），并且具有稳定血块回缩的良好能力。 （IC50，19-180微克ml（-1））。对于这些油，已证明抗血小板效力与苯丙烷类化合物含量（54-86％）之间存在显着相关性，从而表明该部分在预防血凝块形成中起关键作用。这些发现提供了在对含有苯丙烷的天然产物进行药理筛选时考虑到抗血小板活性的基本原理。

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