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首页> 外文期刊>Life sciences >Amelioration of dextran sulfate sodium-induced colitis in mice by oral administration of beta-caryophyllene, a sesquiterpene.
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Amelioration of dextran sulfate sodium-induced colitis in mice by oral administration of beta-caryophyllene, a sesquiterpene.

机译：通过口服给予倍半萜β-叶绿素可以改善小鼠葡聚糖硫酸钠引起的结肠炎。

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摘要

beta-Caryophyllene (BCP), a naturally occurring plant sesquiterpene, was examined for anti-inflammatory activity in a mouse model of experimental colitis induced by dextran sulfate sodium (DSS). Colitis was induced by exposing male BALB/c mice to 5% DSS in drinking water for 7 days. BCP in doses of 30 and 300 mg/kg was administered orally once a day, beginning concurrently with exposure to DSS. The body weight and colon length were measured, and histological damage and myeloperoxidase (MPO) activity as well as inflammatory cytokines were assessed in both serum and colonic tissue after 7 days of treatment with DSS. The DSS treatment damaged the colonic tissue, increased MPO activity and inflammatory cytokines, lowered the body weight, and shortened the length of the colon. Oral administration of BCP at 300 mg/kg significantly suppressed the shortening of colon length and slightly offset the loss of body weight. BCP treatment (300 mg/kg) also significantly reduced the inflammation of colon and reversed the increase in MPO activity that had been induced by exposure to DSS. Further, BCP significantly suppressed the serum level of IL-6 protein (a 55% reduction) as well as the level of IL-6 mRNA in the tissue. These results demonstrate that BCP ameliorates DSS-induced experimental colitis, and may be useful in the prevention and treatment of colitis.
机译：在由葡聚糖硫酸钠（DSS）诱导的实验性结肠炎的小鼠模型中，对天然植物倍半萜β-石竹烯（BCP）的抗炎活性进行了检查。通过使雄性BALB / c小鼠在饮用水中的5％DSS中暴露7天来诱发结肠炎。每天一次口服BCP，剂量为30和300 mg / kg，从接触DSS开始。用DSS治疗7天后，测量体重和结肠长度，并评估血清和结肠组织的组织学损伤和髓过氧化物酶（MPO）活性以及炎性细胞因子。 DSS处理损害了结肠组织，增加了MPO活性和炎性细胞因子，降低了体重，并缩短了结肠的长度。口服300 mg / kg的BCP可以显着抑制结肠长度的缩短，并可以抵消体重的减轻。 BCP处理（300 mg / kg）也显着减少了结肠的炎症，并逆转了由于暴露于DSS而引起的MPO活性的增加。此外，BCP显着抑制了血清中IL-6蛋白的水平（降低了55％）以及组织中IL-6 mRNA的水平。这些结果表明，BCP改善了DSS诱导的实验性结肠炎，并且可能在预防和治疗结肠炎中有用。

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