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首页> 外文期刊>Life sciences >Effects of anethole and structural analogues on the contractility of rat isolated aorta: Involvement of voltage-dependent Ca2+-channels
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Effects of anethole and structural analogues on the contractility of rat isolated aorta: Involvement of voltage-dependent Ca2+-channels

机译：茴香脑和结构类似物对大鼠离体主动脉收缩性的影响：电压依赖性Ca 2+通道的参与

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Anethole is a naturally occurring aromatic oxidant, present in a variety of medicinal plant extracts, which is commonly used by the food and beverage industry. Despite its widespread occurrence and commercial use, there is currently little information regarding effects of this compound on the vasculature. Therefore the actions of anethole on the contractility of rat isolated aorta were compared with those of eugenol, and their respective isomeric forms, estragole and isoeugenol. In aortic rings precontracted with phenylephrine (PE; 1 mu M), anethole (10(-6) M- 10(-4) M) induced contraction in preparations possessing an intact endothelium, but not in endothelium-denuded tissues. At higher concentrations (10(-3) M-10(-2) M), anethole-induced concentration-dependent and complete relaxation of all precontracted preparations, irrespective of whether the endothelium was intact or not, an action shared by eugenol, estragole and isoeugenol. The contractile and relaxant effects of anethole in PE-precontracted preparations were not altered by L-NAME (10 mu M) or indomethacin (10 mu M), indicating that neither nitric oxide nor prostaglandins were involved in these actions. The mixed profile of effects was not confined to PE-mediated contraction, since similar responses were obtained to anethole when tissues were precontracted with 25 mM KCl. Anethole and estragole (10(-6)-10(-4) M), but not eugenol or isoeugenol, increased the basal tonus of endothelium-denuded aortic rings, an action that was abolished by VDCC blockers nifedipine (1 mu M) and diltiazem (1 mu M), or by withdrawal of extracellular Ca2+. Our data suggest complex effects of anethole on isolated blood vessels, inducing contraction at lower doses, mediated via opening of voltage-dependent Ca2+-channels, and relaxant effects at higher concentrations that are shared by structural analogues. (C) 2007 Elsevier Inc. All rights reserved.
机译：茴香脑是一种天然存在的芳香族氧化剂，存在于多种药用植物提取物中，通常被食品和饮料工业使用。尽管其广泛出现和商业用途，但是目前关于该化合物对脉管系统的作用的信息很少。因此，比较了茴香脑与丁子香酚对大鼠离体主动脉收缩力的作用，以及它们各自的异构体形式，雌二醇和异丁香酚。在与去氧肾上腺素（PE; 1μM）预收缩的主动脉环中，茴香脑（10（-6）M-10（-4）M）在具有完整内皮的制剂中诱导收缩，但在内皮剥除的组织中不收缩。在较高的浓度下（10（-3）M-10（-2）M），茴香脑诱导浓度依赖性和所有预收缩制剂的完全松弛，而不论内皮是否完整，丁香酚，雌蕊共有的作用和异丁香酚。 L-NAME（10μM）或消炎痛（10μM）并没有改变茴香脑在PE收缩制剂中的收缩和松弛作用，表明这些作用均不涉及一氧化氮和前列腺素。混合的效果不仅仅局限于PE介导的收缩，因为当组织预先用25 mM KCl收缩时，对茴香脑也有类似的反应。茴香脑和雌草酮（10（-6）-10（-4）M）而非丁子香酚或异丁香酚增加了内皮剥除的主动脉环的基础张力，这一作用已被VDCC阻滞剂硝苯地平（1μM）和地尔硫卓（1μM）或通过撤出细胞外Ca2 +我们的数据表明茴香脑对离体血管的复杂作用，以较低剂量诱导收缩（通过打开电压依赖性Ca2 +通道介导）以及在较高浓度下由结构类似物共享的松弛作用。 （C）2007 Elsevier Inc.保留所有权利。

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