EOSINOPHIL CHARCOT-LEYDEN CRYSTAL PROTEIN BINDS TO BETA-GALACTOSIDE SUGARS

Dyer KD.; Rosenberg HF.

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EOSINOPHIL CHARCOT-LEYDEN CRYSTAL PROTEIN BINDS TO BETA-GALACTOSIDE SUGARS

机译：嗜酸性夏洛特晶体蛋白与β-半乳糖苷结合

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The Charcot-Leyden crystal protein (CLC) found in human eosinophils and basophils has 43-48% amino acid sequence similarity to the galectin family of beta-galactoside binding proteins. We show here that enzymatically active recombinant CLC binds to a lactose-conjugated agarose resin, and that binding is inhibited in a dose dependent fashion by both lactose (IC50 = 41 mM) and fucose (IC50 = 380 mM), but not by arabinose. These results demonstrate that CLC has functional as well as structural homology to the galectins, and suggest that CLC may also participate, as do the galectins, in mediating cell-cell and cell-matrix interactions, and in activating the cellular immune response. [References: 44]

机译：在人类嗜酸性粒细胞和嗜碱性粒细胞中发现的Charcot-Leyden晶体蛋白（CLC）与β-半乳糖苷结合蛋白的半乳凝素家族具有43-48％的氨基酸序列相似性。我们在这里显示了具有酶活性的重组CLC结合到乳糖缀合的琼脂糖树脂上，并且乳糖（IC50 = 41 mM）和岩藻糖（IC50 = 380 mM）都以剂量依赖的方式抑制了结合，但阿拉伯糖则没有。这些结果表明，CLC与半乳凝素具有功能和结构同源性，并且表明CLC也可以像半乳凝素一样参与介导细胞-细胞和细胞-基质的相互作用以及激活细胞免疫应答。 [参考：44]

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《Life sciences》 |1996年第23期|共10页
作者
Dyer KD.; Rosenberg HF.;
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正文语种 eng
中图分类生命的起源;生命科学总论;
关键词
Eosinophil; Charcot-leyden crystal protein; Beta-galactoside sugars; Molecular-cloning; Animal lectin; Selective expression; Escherichia-coli; Muscle lectin; Epsilon-bp; Mast-cells; Lactose; Ige; Lysophospholipase;

机译：嗜酸性粒细胞;夏洛特晶体蛋白;β-半乳糖苷;分子克隆;动物凝集素;选择性表达;大肠杆菌;肌凝集素;Epsilon-bp;肥大细胞;乳糖;Ige;溶血磷脂酶;

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1. EOSINOPHIL CHARCOT-LEYDEN CRYSTAL PROTEIN BINDS TO BETA-GALACTOSIDE SUGARS [J] . Dyer KD., Rosenberg HF. Life sciences . 1996,第23期

机译：嗜酸性夏洛特晶体蛋白与β-半乳糖苷结合
2. Selective recognition of mannose by the human eosinophil Charcot-Leyden crystal protein (galectin-10): a crystallographic study at 1.8 A resolution. [J] . Swaminathan GJ, Leonidas DD, Savage MP, Biochemistry . 1999,第42期

机译：人类嗜酸性粒细胞Charcot-Leyden晶体蛋白（galectin-10）对甘露糖的选择性识别：1.8 A分辨率的晶体学研究。
3. Selective recognition of mannose by human eosinophil charcot-leyden crystal protein (galectin-10): a crystallographic study at 1.8 A resolution [J] . G.Jawahar Swaminathan, Demetrios D.Leonidas, Michael P.Savage Biochemistry . 1999,第42期

机译：人类嗜酸性粒细胞夏洛特-莱登晶体蛋白（galectin-10）对甘露糖的选择性识别：1.8 A分辨率的晶体学研究
4. Sugar-sensitive FRET biosensor based on concerted conformational change of binding protein and fluorescent protein [C] . China-Japan-Korea Joint Symposium on Enzyme Engineering . 2004

机译：基于结合蛋白和荧光蛋白协同构象变化的糖敏感性FRET生物传感器
5. Eosinophil pathobiology: Roles of lysophospholipases and Charcot-Leyden crystal protein/galectin-10. [D] . Doyle, Christine B. 2009

机译：嗜酸性粒细胞病理生物学：溶血磷脂酶和Charcot-Leyden晶体蛋白/ galectin-10的作用。
6. Comparative properties of the Charcot-Leyden crystal protein and the major basic protein from human eosinophils. [O] . G J Gleich, D A Loegering, K G Mann, 1976

机译：Charcot-Leyden晶体蛋白与人类嗜酸性粒细胞的主要碱性蛋白的比较特性。
7. Selective Recognition of Mannose by the Human Eosinophil Charcot-Leyden Crystal Protein (Galectin-10): A Crystallographic Study at 1.8 Å Resolution [O] . G. Jawahar Swaminathan, Demetrios D. Leonidas, Michael P. Savage, 1999

机译：人嗜酸性粒细胞Charcot-Leyden晶粒（Galectin-10）的选择性识别甘露糖（Galectin-10）：分辨率为1.8的晶体研究

EOSINOPHIL CHARCOT-LEYDEN CRYSTAL PROTEIN BINDS TO BETA-GALACTOSIDE SUGARS

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