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首页> 外文期刊>Life sciences >MODULATION OF NMDA AND DOPAMINERGIC NEUROTRANSMISSIONS BY SIGMA LIGANDS - POSSIBLE IMPLICATIONS FOR THE TREATMENT OF PSYCHIATRIC DISORDERS [Review]
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MODULATION OF NMDA AND DOPAMINERGIC NEUROTRANSMISSIONS BY SIGMA LIGANDS - POSSIBLE IMPLICATIONS FOR THE TREATMENT OF PSYCHIATRIC DISORDERS [Review]

机译：SIGMA LIGANDS对NMDA和多巴胺能神经传递的调节-对治疗精神障碍的可能意义[综述]

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Sigma (sigma) receptors, improperly classified as belonging to the opiate receptor family when discovered in 1976, were subsequently confused with phencyclidine binding sites for several years. It's only recently, with the emergence of new selective ligands that their functional significance could be meaningfully addressed. Several subtypes of sigma receptors are present in high densities in the limbic structures as well as in motor-related areas of the CNS. Different lines of evidence suggest that a major role for sigma receptors might be to regulate the activity of the glutamatergic system via the modulation one of its subtype of receptor, the NMDA receptor. This modulation of the glutamatergic system could in turn interfere with the dopaminergic neurotransmission with which, however, sigma ligands could also interact directly. [References: 179]
机译：1976年发现时，西格玛（sigma）受体被错误地归类为阿片受体家族，随后几年与苯环利定结合位点相混淆。直到最近，随着新的选择性配体的出现，才可以有意义地解决其功能重要性。西格玛受体的几种亚型以高密度存在于边缘结构以及中枢神经系统的运动相关区域。不同的证据表明，sigma受体的主要作用可能是通过调节其受体亚型之一NMDA受体来调节谷氨酸能系统的活性。谷氨酸能系统的这种调节反过来又会干扰多巴胺能神经传递，但是，sigma配体也可以与之直接相互作用。 [参考：179]

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