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首页> 外文期刊>Life sciences >ELEVATED NORHARMAN PLASMA LEVELS IN ALCOHOLIC PATIENTS AND CONTROLS RESULTING FROM TOBACCO SMOKING
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ELEVATED NORHARMAN PLASMA LEVELS IN ALCOHOLIC PATIENTS AND CONTROLS RESULTING FROM TOBACCO SMOKING

机译：烟酒中诺拉曼血浆水平升高和烟尘控制

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摘要

Plasma norharman and harman levels were measured by solvent extraction and HPLC with fluorescence detection in alcohol-dependent patients undergoing in-patient abstinence treatment and in control subjects. In both groups, randomly collected samples from smokers contained higher mean norharman levels than those from nonsmokers. In three volunteers norharman concentrations rose sharply after smoking of one or two cigarettes and declined to near-basal levels within one hour after one cigarette. When 12 patients kept a smoking-free interval of at least 6 h, they had similarly low plasma norharman concentrations (20 +/- 8 pg/ml) as 18 non-smoking control subjects (17 +/- 8 pg/ml) or as 13 smoking controls who had abstained from smoking (20 +/- 6 pg/ml). Ten of the patients smoked one cigarette and within 5 - 10 min attained norharman levels of 177 +/- 147 pg/ml plasma. The high prevalence of smokers among chronic alcoholics probably explains the previous finding of elevated norharman plasma levels in these patients. [References: 28]
机译：通过溶剂提取和高效液相色谱法（HPLC）以及荧光检测，对接受住院戒酒治疗的酒精依赖患者和对照组的血浆诺曼曼和哈曼水平进行测量。在两组中，从吸烟者中随机采集的样本均比非吸烟者中的平均诺哈曼浓度更高。在三名志愿者中，诺哈曼浓度在吸烟一两支烟后急剧上升，并在一支烟后一小时内降至接近基本水平。当12名患者的无烟间隔时间至少为6小时时，他们的血浆诺氏浓度（18 +/- 8 pg / ml）与18例非吸烟对照者（17 +/- 8 pg / ml）相似，或作为13位戒烟的吸烟者（20 +/- 6 pg / ml）。十名患者抽了一支烟，并在5-10分钟内达到诺哈曼血浆浓度177 +/- 147 pg / ml。慢性酒精中毒烟民的高患病率可能解释了先前在这些患者中诺哈曼血浆水平升高的发现。 [参考：28]

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