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首页> 外文期刊>Life sciences >INVOLVEMENT OF D-ASPARTIC ACID IN THE SYNTHESIS OF TESTOSTERONE IN RAT TESTES
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INVOLVEMENT OF D-ASPARTIC ACID IN THE SYNTHESIS OF TESTOSTERONE IN RAT TESTES

机译：D-天冬氨酸在大鼠睾丸激素合成中的参与

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摘要

D-Aspartic acid (D-Asp) is an endogenous amino acid which occurs in many marine and terrestrial animals. In fetal and young rats, this amino acid occurs prevalently in nervous tissue, whereas at sexual maturity it occurs in endocrine glands and above all in pituitary and testes. Here, we have studied if a relationship exists between the presence of D-Asp and the hormonal activity. The following results were obtained: 1) Both D-Asp and testosterone are synthesized in rat testes in two periods of the animal's life: before birth, about the 17th day after fertilization and, after birth, at sexual maturity. 2) Immunocytochemical studies have demonstrated that this enantiomer is localized in Leydig and Sertoli cells. 3) In vivo experiments, consisting of i.p. injection of D-Asp to adult male rats, demonstrated that this amino acid accumulates in pituitary and testis (after 5 h, the accumulation was of 12 and 4-fold over basal values, respectively); simultaneously, luteinizing hormone, testosterone and progesterone significantly increased in the blood (1.6-fold, p<0.05; 3.0-fold, p<0.01 and 2.9-fold, p<0.01, respectively). 4) Finally, in vitro experiments, consisting of the incubation of D-Asp with isolated testes also demonstrated that this amino acid induces the synthesis of testosterone. These results suggest that free D-Asp is involved in the steroidogenesis. [References: 17]
机译：D-天冬氨酸（D-Asp）是一种内源性氨基酸，它存在于许多海洋和陆生动物中。在胎儿和年幼大鼠中，该氨基酸普遍存在于神经组织中，而在性成熟时，其存在于内分泌腺中，尤其是在垂体和睾丸中。在这里，我们研究了D-Asp的存在与激素活性之间是否存在关系。获得了以下结果：1）D-Asp和睾丸素均在动物生命的两个阶段在大鼠睾丸中合成：出生前，受精后第17天以及出生后性成熟。 2）免疫细胞化学研究表明，该对映异构体位于Leydig和Sertoli细胞中。 3）体内实验，由i.p.向成年雄性大鼠注射D-Asp，表明该氨基酸在垂体和睾丸中积累（5小时后，其积累量分别是基础值的12倍和4倍）;同时，血液中的黄体生成素，睾丸激素和孕酮显着增加（分别为1.6倍，p <0.05; 3.0倍，p <0.01和2.9倍，p <0.01）。 4）最后，体外实验（包括将D-Asp与分离的睾丸一起孵育）也证明了该氨基酸可诱导睾丸激素的合成。这些结果表明游离的D-Asp参与类固醇生成。 [参考：17]

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