• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Protective effects of Danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunction
【24h】

Protective effects of Danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunction

机译：丹参水提物中丹参素对高半胱氨酸诱导的内皮功能障碍的保护作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Homocysteine (Hcy) is a by-product of methionine metabolism. An imbalance of Hcy in the body may lead to hyperhomocysteinemia, a condition with elevated Hcy concentration in blood that may be one of the risk factors responsible for the development of several vascular diseases (thromboembolism, atherosclerosis, stroke, vascular diseases and dementia). Radix Salvia miltiorrhiza (Danshen), a well-known Chinese medicinal herb that can activate and improve blood microcirculation, is noticeable for its beneficial effect in treating cardiovascular diseases. The present study is to demonstrate the protective effect of Danshen extract against the homocysteine-induced adverse effect on human umbilical vein endothelial cell (HUVEC). Homocysteine (5 mM) not only decreased the cell viability but also caused the disruption of capillary-like structure formation in vitro. The protective effect of Danshen aqueous extract and its active compounds on endothelial cell function were demonstrated. through an in vitro tube formation assay, which mimics the-new blood vessel formation. To identify the active components in the aqueous extract of Danshen, the content was characterized by instrumental analysis using high performance liquid chromatography with diode array detector (DAD) and electrospray tandem mass spectrometry (ESI-MS/MS). Interestingly, Danshen extract and its pure compounds showed different effectiveness in protecting HUVEC against Hcy-induced injury according to the following descending order: Danshen aqueous extract, 3-(3,4-dihydroxy-phenyl)-2-hydroxy-propionic acid (Danshensu), protocatechuic acid, catechin and protocatechualdehyde.. We believed that such findings might provide evidence in understanding the beneficial effects of Danshen on the cardiovascular system. (C) 2004 Elsevier Inc. All rights reserved.
机译：同型半胱氨酸（Hcy）是蛋氨酸代谢的副产物。体内Hcy的失衡可能导致高同型半胱氨酸血症，血液中Hcy浓度升高可能是导致多种血管疾病（血栓栓塞，动脉粥样硬化，中风，血管疾病和痴呆症）发展的危险因素之一。丹参（丹参）是一种著名的中草药，可以激活和改善血液微循环，因其在治疗心血管疾病方面的有益作用而引人注目。本研究旨在证明丹参提取物对高半胱氨酸诱导的对人脐静脉内皮细胞（HUVEC）的不良作用的保护作用。同型半胱氨酸（5 mM）不仅降低了细胞活力，而且还破坏了体外毛细管样结构的形成。证明了丹参水提物及其活性成分对内皮细胞功能的保护作用。通过模仿新血管形成的体外试管形成试验。为了鉴定丹参水提物中的活性成分，使用高效液相色谱仪和二极管阵列检测器（DAD）和电喷雾串联质谱仪（ESI-MS / MS）对仪器进行分析，以分析其含量。有趣的是，丹参提取物及其纯化合物在保护HUVEC免受Hcy诱导的伤害方面具有以下不同的降序作用：丹参水提取物，3-（3,4-二羟基-苯基）-2-羟基-丙酸（Danshensu） ），原儿茶酸，儿茶素和原儿茶醛。我们相信，这些发现可能为理解丹参对心血管系统的有益作用提供证据。 （C）2004 Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号