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首页> 外文期刊>Life sciences >Age and monosodium glutamate treatment cause changes in the stimulation-induced [H-3]-norepinephrine release from rat nucleus tractus solitarii-dorsal vagal nucleus slices
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Age and monosodium glutamate treatment cause changes in the stimulation-induced [H-3]-norepinephrine release from rat nucleus tractus solitarii-dorsal vagal nucleus slices

机译：年龄和味精处理引起刺激的大鼠孤束腹背迷走神经核切片[H-3]-去甲肾上腺素释放变化

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摘要

In nucleus tractus solitarii-dorsal vagal nucleus slices prepared from young adult rats (180-260 g) 10(-3) M L-glutamate and 10(-5) M baclofen caused a 2-3-fold increase of field stimulation-induced [H-3]-norepinephrine release without affecting the resting release. In slices prepared from rats treated neonatally with monosodium glutamate neither L-glutamate nor baclofen had any effect on stimulation-induced norepinephrine release, tested between postnatal days 74-99 (350-530 g). In untreated littermates used in the same period (460-580 g) L-glutamate was fully effective whereas baclofen was ineffective. The tritium content in tissue extracts did not differ significantly in the three experimental groups. It is concluded that i) the loss of GABA(B) receptor-mediated disinhibitory stimulation of norepinephrine release is an age-related phenomenon and ii) neonatal monosodium glutamate treatment causes a damage in the local neural circuitry characterized by the loss of glutamate receptor-mediated mechanism that stimulates the release of norepinephrine. (C) 2003 Elsevier Inc. All rights reserved. [References: 28]
机译：在幼年成年大鼠（180-260 g）10（-3）M L-谷氨酸和10（-5）M baclofen制备的孤束核背侧迷走神经核切片中，电场刺激诱导的2到3倍增加[H-3]去甲肾上腺素释放而不影响静止释放。在产后第74-99天（350-530 g）之间测试，在用谷氨酸一钠新生治疗的大鼠制成的切片中，L-谷氨酸和巴氯芬均对刺激诱导的去甲肾上腺素释放没有任何影响。在同期使用的未经处理的同窝仔猪（460-580 g）中，L-谷氨酸完全有效，而巴氯芬无效。在三个实验组中，组织提取物中的t含量没有显着差异。结论是：i）去甲肾上腺素释放的GABA（B）受体介导的去抑制性刺激的丧失是一种与年龄有关的现象，并且ii）新生的谷氨酸一钠治疗引起局部神经回路的损害，其特征在于谷氨酸受体的丧失。介导刺激去甲肾上腺素释放的机制。 （C）2003 Elsevier Inc.保留所有权利。 [参考：28]

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